Tags

Type your tag names separated by a space and hit enter

Effects of three-day oral cholecystography on serum iodothyronines and TSH concentrations: comparison of the effects among some cholecystographic agents and the effects of iopanoic acid on the pituitary-thyroid axis.
Acta Endocrinol (Copenh). 1979 Nov; 92(3):477-88.AE

Abstract

The effects of repeated doses of oral cholecystographic agents on serum thyroxine (T4), 3,3',5-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) and thyrotrophin (TSH) concentrations were studied in 37 euthyroid male subjects. Iobenzamic acid, tyropanoic acid, iopanoic acid, and ipodate sodium, in a dosage of 3 g for 3 days, respectively, induced a significant decrease in serum T3 and an increase in rT3 within 24 h after the initial dose, followed by an increase in TSH and a slight increase in T4. The extent of the changes in rT3 varied between the agents, ipodate causing the greatest change, but without any relation to the changes in T3 or T4. Responses of serum T4, T3, rT3 and TSH concentrations to exogenous thyrotrophin-releasing hormone (TRH) and bovine TSH were also studied before and after 3-day doses of iopanoic acid. In 11 subjects given iopanoic acid, the response to TSH to TRH (500 micrograms, iv) was increased but the T3 response was unchanged. A dose of TSH (10 U.S.P. units, im) caused a significant increase in serum T3 and a decrease in TSH concentrations in 5 subjects both before and after cholecystography. It is thus suggested that in euthyroid subjects given multiple doses of oral cholecystographic agents, (1) the primary and consistent events are the reciprocal changes of serum T3 and RT3, although the extent of the changes is not coordinately reciprocal; (2) the responsiveness of the pituitary thyrotrophs and thyroid to TRH is preserved; and (3) the high basal and TRH-induced TSH in the serum may be ascribed to the decrease in the serum T3 concentration.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

517049

Citation

Suzuki, H, et al. "Effects of Three-day Oral Cholecystography On Serum Iodothyronines and TSH Concentrations: Comparison of the Effects Among some Cholecystographic Agents and the Effects of Iopanoic Acid On the Pituitary-thyroid Axis." Acta Endocrinologica, vol. 92, no. 3, 1979, pp. 477-88.
Suzuki H, Kadena N, Takeuchi K, et al. Effects of three-day oral cholecystography on serum iodothyronines and TSH concentrations: comparison of the effects among some cholecystographic agents and the effects of iopanoic acid on the pituitary-thyroid axis. Acta Endocrinol (Copenh). 1979;92(3):477-88.
Suzuki, H., Kadena, N., Takeuchi, K., & Nakagawa, S. (1979). Effects of three-day oral cholecystography on serum iodothyronines and TSH concentrations: comparison of the effects among some cholecystographic agents and the effects of iopanoic acid on the pituitary-thyroid axis. Acta Endocrinologica, 92(3), 477-88.
Suzuki H, et al. Effects of Three-day Oral Cholecystography On Serum Iodothyronines and TSH Concentrations: Comparison of the Effects Among some Cholecystographic Agents and the Effects of Iopanoic Acid On the Pituitary-thyroid Axis. Acta Endocrinol (Copenh). 1979;92(3):477-88. PubMed PMID: 517049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of three-day oral cholecystography on serum iodothyronines and TSH concentrations: comparison of the effects among some cholecystographic agents and the effects of iopanoic acid on the pituitary-thyroid axis. AU - Suzuki,H, AU - Kadena,N, AU - Takeuchi,K, AU - Nakagawa,S, PY - 1979/11/1/pubmed PY - 1979/11/1/medline PY - 1979/11/1/entrez SP - 477 EP - 88 JF - Acta endocrinologica JO - Acta Endocrinol (Copenh) VL - 92 IS - 3 N2 - The effects of repeated doses of oral cholecystographic agents on serum thyroxine (T4), 3,3',5-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) and thyrotrophin (TSH) concentrations were studied in 37 euthyroid male subjects. Iobenzamic acid, tyropanoic acid, iopanoic acid, and ipodate sodium, in a dosage of 3 g for 3 days, respectively, induced a significant decrease in serum T3 and an increase in rT3 within 24 h after the initial dose, followed by an increase in TSH and a slight increase in T4. The extent of the changes in rT3 varied between the agents, ipodate causing the greatest change, but without any relation to the changes in T3 or T4. Responses of serum T4, T3, rT3 and TSH concentrations to exogenous thyrotrophin-releasing hormone (TRH) and bovine TSH were also studied before and after 3-day doses of iopanoic acid. In 11 subjects given iopanoic acid, the response to TSH to TRH (500 micrograms, iv) was increased but the T3 response was unchanged. A dose of TSH (10 U.S.P. units, im) caused a significant increase in serum T3 and a decrease in TSH concentrations in 5 subjects both before and after cholecystography. It is thus suggested that in euthyroid subjects given multiple doses of oral cholecystographic agents, (1) the primary and consistent events are the reciprocal changes of serum T3 and RT3, although the extent of the changes is not coordinately reciprocal; (2) the responsiveness of the pituitary thyrotrophs and thyroid to TRH is preserved; and (3) the high basal and TRH-induced TSH in the serum may be ascribed to the decrease in the serum T3 concentration. SN - 0001-5598 UR - https://www.unboundmedicine.com/medline/citation/517049/Effects_of_three_day_oral_cholecystography_on_serum_iodothyronines_and_TSH_concentrations:_comparison_of_the_effects_among_some_cholecystographic_agents_and_the_effects_of_iopanoic_acid_on_the_pituitary_thyroid_axis_ DB - PRIME DP - Unbound Medicine ER -