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Normal response to thyrotrophin releasing hormone (TRH) in familial thyroxine-binding globulin deficiency.
Acta Endocrinol (Copenh). 1975 Oct; 80(2):279-301.AE

Abstract

The response in serum thyrotrophin (TSH) to thyrotrophin releasing hormone (TRH) has been studied in 5 euthyroid patients with familial thyroxine-binding globulin (TBG) deficiency. Total serum thyroxine (T4), serum triiodothyronine (T3) and free T4 index and free T3 index were significantly and equally decreased, but in spite of these findings the serum TSH and response to TRH was normal. The TRH test seems to be a better indicator of the euthyroid state in familial TBG deficiency than the measurement of free T4 and free T3 in serum.

Authors

Hansen E
No affiliation info available
Kirkegaard C
No affiliation info available
Friis T
No affiliation info available
Siersbaek-Nielsen K
No affiliation info available

MeSH

AdultAlpha-GlobulinsFemaleHumansMaleMiddle AgedThyrotropinThyrotropin-Releasing HormoneThyroxineThyroxine-Binding ProteinsTriiodothyronine

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

52266

Citation

Hansen, E, et al. "Normal Response to Thyrotrophin Releasing Hormone (TRH) in Familial Thyroxine-binding Globulin Deficiency." Acta Endocrinologica, vol. 80, no. 2, 1975, pp. 279-301.
Hansen E, Kirkegaard C, Friis T, et al. Normal response to thyrotrophin releasing hormone (TRH) in familial thyroxine-binding globulin deficiency. Acta Endocrinol (Copenh). 1975;80(2):279-301.
Hansen, E., Kirkegaard, C., Friis, T., & Siersbaek-Nielsen, K. (1975). Normal response to thyrotrophin releasing hormone (TRH) in familial thyroxine-binding globulin deficiency. Acta Endocrinologica, 80(2), 279-301.
Hansen E, et al. Normal Response to Thyrotrophin Releasing Hormone (TRH) in Familial Thyroxine-binding Globulin Deficiency. Acta Endocrinol (Copenh). 1975;80(2):279-301. PubMed PMID: 52266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Normal response to thyrotrophin releasing hormone (TRH) in familial thyroxine-binding globulin deficiency. AU - Hansen,E, AU - Kirkegaard,C, AU - Friis,T, AU - Siersbaek-Nielsen,K, PY - 1975/10/1/pubmed PY - 1975/10/1/medline PY - 1975/10/1/entrez SP - 279 EP - 301 JF - Acta endocrinologica JO - Acta Endocrinol (Copenh) VL - 80 IS - 2 N2 - The response in serum thyrotrophin (TSH) to thyrotrophin releasing hormone (TRH) has been studied in 5 euthyroid patients with familial thyroxine-binding globulin (TBG) deficiency. Total serum thyroxine (T4), serum triiodothyronine (T3) and free T4 index and free T3 index were significantly and equally decreased, but in spite of these findings the serum TSH and response to TRH was normal. The TRH test seems to be a better indicator of the euthyroid state in familial TBG deficiency than the measurement of free T4 and free T3 in serum. SN - 0001-5598 UR - https://www.unboundmedicine.com/medline/citation/52266/Normal_response_to_thyrotrophin_releasing_hormone__TRH__in_familial_thyroxine_binding_globulin_deficiency_ DB - PRIME DP - Unbound Medicine ER -
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