Tags

Type your tag names separated by a space and hit enter

Response of the fetal and newborn lamb to glucose and tolbutamide infusions.
Pediatr Res 1979; 13(12):1375-8PR

Abstract

Tolbutamide infused into the chronically catheterized sheep fetus produced significant secretion of insulin. An optimal dose range of 100-200 mg/kg estimated fetal weight was demonstrated. Paired tolbutamide and glucose infusions using a square wave technique demonstrated that although early phase insulin secretion is dimished in the fetus, this is not due to an absolute deficiency of stored insulin. Tolbutamide produced peak insulin concentrations of 51.6 +/- 9.0 muu/ml by 20 min postinfusion in the fetus. When similar tolbutamide infusions were performed in neonatal lambs, qualitatively similar insulin response curves were demonstrated although peak insulin levels were much greater (260 +/- 70 muu/ml at 20 min). A fall in plasma glucose was demonstrated in both fetal and neonatal lambs (to 75 and 39% of control values, respectively) by 60 min after tolbutamide infusion. In the fetus, this fall was not associated with changes in maternal glucose concentration.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

523198

Citation

Philipps, A F., et al. "Response of the Fetal and Newborn Lamb to Glucose and Tolbutamide Infusions." Pediatric Research, vol. 13, no. 12, 1979, pp. 1375-8.
Philipps AF, Dubin JW, Raye JR. Response of the fetal and newborn lamb to glucose and tolbutamide infusions. Pediatr Res. 1979;13(12):1375-8.
Philipps, A. F., Dubin, J. W., & Raye, J. R. (1979). Response of the fetal and newborn lamb to glucose and tolbutamide infusions. Pediatric Research, 13(12), pp. 1375-8.
Philipps AF, Dubin JW, Raye JR. Response of the Fetal and Newborn Lamb to Glucose and Tolbutamide Infusions. Pediatr Res. 1979;13(12):1375-8. PubMed PMID: 523198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Response of the fetal and newborn lamb to glucose and tolbutamide infusions. AU - Philipps,A F, AU - Dubin,J W, AU - Raye,J R, PY - 1979/12/1/pubmed PY - 1979/12/1/medline PY - 1979/12/1/entrez SP - 1375 EP - 8 JF - Pediatric research JO - Pediatr. Res. VL - 13 IS - 12 N2 - Tolbutamide infused into the chronically catheterized sheep fetus produced significant secretion of insulin. An optimal dose range of 100-200 mg/kg estimated fetal weight was demonstrated. Paired tolbutamide and glucose infusions using a square wave technique demonstrated that although early phase insulin secretion is dimished in the fetus, this is not due to an absolute deficiency of stored insulin. Tolbutamide produced peak insulin concentrations of 51.6 +/- 9.0 muu/ml by 20 min postinfusion in the fetus. When similar tolbutamide infusions were performed in neonatal lambs, qualitatively similar insulin response curves were demonstrated although peak insulin levels were much greater (260 +/- 70 muu/ml at 20 min). A fall in plasma glucose was demonstrated in both fetal and neonatal lambs (to 75 and 39% of control values, respectively) by 60 min after tolbutamide infusion. In the fetus, this fall was not associated with changes in maternal glucose concentration. SN - 0031-3998 UR - https://www.unboundmedicine.com/medline/citation/523198/Response_of_the_fetal_and_newborn_lamb_to_glucose_and_tolbutamide_infusions_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=523198.ui DB - PRIME DP - Unbound Medicine ER -