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[Density of cerebrospinal fluid and local anesthetics (author's transl)].
Anaesthesist. 1979 Oct; 28(10):81-3.A

Abstract

The densities of cerebrospinal fluid and of local anesthetics, applicable to isobaric spinal anesthesia, were determined by using the Digital Density Meter DMA 02. The density of CSF showed little variation and at 37 degrees C was 1.00021 +/- 0.00024 g/cm3 (mean +/- SD, n = 22). The density of the local anesthetics bupivacaine 0.5%, carticaine 2%, lidocaine 2%, mepivacaine 2% and prilocaine 2% varied at 25 degrees C between 1.001 and 1.005 g/cm3, at 37 degrees C between 0.997 and 1.001 g/cm3. Tetracaine 0.5% in CBF increased its density by 0.00046 g/cm3. The addition of the vasoconstrictors adrenaline and ornipressine (POR 8) increased the density of the local anesthetic solutions insignificantly. On the basis of the narrow range of variation of CSF density, reliable statements may be made on the density dependent spread of local anesthetics in spinal anesthesia.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

525747

Citation

Becker, J, et al. "[Density of Cerebrospinal Fluid and Local Anesthetics (author's Transl)]." Der Anaesthesist, vol. 28, no. 10, 1979, pp. 81-3.
Becker J, Theiss D, Lanz E, et al. [Density of cerebrospinal fluid and local anesthetics (author's transl)]. Anaesthesist. 1979;28(10):81-3.
Becker, J., Theiss, D., Lanz, E., & Erdmann, K. (1979). [Density of cerebrospinal fluid and local anesthetics (author's transl)]. Der Anaesthesist, 28(10), 81-3.
Becker J, et al. [Density of Cerebrospinal Fluid and Local Anesthetics (author's Transl)]. Anaesthesist. 1979;28(10):81-3. PubMed PMID: 525747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Density of cerebrospinal fluid and local anesthetics (author's transl)]. AU - Becker,J, AU - Theiss,D, AU - Lanz,E, AU - Erdmann,K, PY - 1979/10/1/pubmed PY - 1979/10/1/medline PY - 1979/10/1/entrez SP - 81 EP - 3 JF - Der Anaesthesist JO - Anaesthesist VL - 28 IS - 10 N2 - The densities of cerebrospinal fluid and of local anesthetics, applicable to isobaric spinal anesthesia, were determined by using the Digital Density Meter DMA 02. The density of CSF showed little variation and at 37 degrees C was 1.00021 +/- 0.00024 g/cm3 (mean +/- SD, n = 22). The density of the local anesthetics bupivacaine 0.5%, carticaine 2%, lidocaine 2%, mepivacaine 2% and prilocaine 2% varied at 25 degrees C between 1.001 and 1.005 g/cm3, at 37 degrees C between 0.997 and 1.001 g/cm3. Tetracaine 0.5% in CBF increased its density by 0.00046 g/cm3. The addition of the vasoconstrictors adrenaline and ornipressine (POR 8) increased the density of the local anesthetic solutions insignificantly. On the basis of the narrow range of variation of CSF density, reliable statements may be made on the density dependent spread of local anesthetics in spinal anesthesia. SN - 0003-2417 UR - https://www.unboundmedicine.com/medline/citation/525747/[Density_of_cerebrospinal_fluid_and_local_anesthetics__author's_transl_]_ DB - PRIME DP - Unbound Medicine ER -
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