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Differential histamine release by dextran and the ionophore A23187: the actions of inhibitors.
Int Arch Allergy Appl Immunol. 1976; 50(1):27-42.IA

Abstract

Inhibitors of mast cell membrane activation reduced histamine release from rat mast cells induced by dextran and phosphatidyl serine but not that induced by the calcium ionophore A23187. Such inhibitors included cromoglycate, an orally-active anti-allergic agent 3-(5-tetrazolyl)thioxanthone 10,10-dioxide, dibutyryl cyclic 3':5'-AMP, theophylline and dicumarol. Inhibitors of mast cell metabolism reduced both types of release and these included oligomycin, papevevime, and the two uncouplers of oxidative phosphorylation-alpha2,4-dinitrophenol and CCCP. Inhibition of histamine release from rat isolated peritoneal mast cells by either a mixture of dextran and phosphatidyl serine or the ionophore A23187 thus allows inhibitors of mast cell membrane activation to be distinguished from those affecting cell metabolism or the later stages of the secretory process.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

52625

Citation

Garland, L G., and J L. Mongar. "Differential Histamine Release By Dextran and the Ionophore A23187: the Actions of Inhibitors." International Archives of Allergy and Applied Immunology, vol. 50, no. 1, 1976, pp. 27-42.
Garland LG, Mongar JL. Differential histamine release by dextran and the ionophore A23187: the actions of inhibitors. Int Arch Allergy Appl Immunol. 1976;50(1):27-42.
Garland, L. G., & Mongar, J. L. (1976). Differential histamine release by dextran and the ionophore A23187: the actions of inhibitors. International Archives of Allergy and Applied Immunology, 50(1), 27-42.
Garland LG, Mongar JL. Differential Histamine Release By Dextran and the Ionophore A23187: the Actions of Inhibitors. Int Arch Allergy Appl Immunol. 1976;50(1):27-42. PubMed PMID: 52625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential histamine release by dextran and the ionophore A23187: the actions of inhibitors. AU - Garland,L G, AU - Mongar,J L, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 27 EP - 42 JF - International archives of allergy and applied immunology JO - Int Arch Allergy Appl Immunol VL - 50 IS - 1 N2 - Inhibitors of mast cell membrane activation reduced histamine release from rat mast cells induced by dextran and phosphatidyl serine but not that induced by the calcium ionophore A23187. Such inhibitors included cromoglycate, an orally-active anti-allergic agent 3-(5-tetrazolyl)thioxanthone 10,10-dioxide, dibutyryl cyclic 3':5'-AMP, theophylline and dicumarol. Inhibitors of mast cell metabolism reduced both types of release and these included oligomycin, papevevime, and the two uncouplers of oxidative phosphorylation-alpha2,4-dinitrophenol and CCCP. Inhibition of histamine release from rat isolated peritoneal mast cells by either a mixture of dextran and phosphatidyl serine or the ionophore A23187 thus allows inhibitors of mast cell membrane activation to be distinguished from those affecting cell metabolism or the later stages of the secretory process. SN - 0020-5915 UR - https://www.unboundmedicine.com/medline/citation/52625/Differential_histamine_release_by_dextran_and_the_ionophore_A23187:_the_actions_of_inhibitors_ DB - PRIME DP - Unbound Medicine ER -