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Comparison of effects on cerebral blood flow of rapid reduction in systemic arterial pressure by diazoxide and labetalol in hypertensive patients: preliminary findings.
Br J Clin Pharmacol. 1979; 8(Suppl 2):195S-198S.BJ

Abstract

1 Diazoxide 300 mg and labetalol 150 mg were each injected intravenously on separate occasions into five patients with essentail hypertension. The reduction in BP caused by labetalol was slightly greater than that produced by diazoxide. 2 In contrast the reduction in cerebral blood flow (CBF) by labetalol was not statistically significant, whereas diazoxide gave a greater and statistically significant reduction in CBF. 3 These observations suggest that labetalol may have an advantage over diazoxide for the rapid reduction in BP.

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Authors

Pearson RM
No affiliation info available
Griffith DN
No affiliation info available
Woollard M
No affiliation info available
James IM
No affiliation info available
Havard CW
No affiliation info available

MeSH

Blood PressureCardiac OutputCerebrovascular CirculationDiazoxideElectrocardiographyEthanolaminesHumansHypertensionLabetalolMaleMiddle AgedPulseStroke Volume

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

526401

Citation

Pearson, R M., et al. "Comparison of Effects On Cerebral Blood Flow of Rapid Reduction in Systemic Arterial Pressure By Diazoxide and Labetalol in Hypertensive Patients: Preliminary Findings." British Journal of Clinical Pharmacology, vol. 8, no. Suppl 2, 1979, 195S-198S.
Pearson RM, Griffith DN, Woollard M, et al. Comparison of effects on cerebral blood flow of rapid reduction in systemic arterial pressure by diazoxide and labetalol in hypertensive patients: preliminary findings. Br J Clin Pharmacol. 1979;8(Suppl 2):195S-198S.
Pearson, R. M., Griffith, D. N., Woollard, M., James, I. M., & Havard, C. W. (1979). Comparison of effects on cerebral blood flow of rapid reduction in systemic arterial pressure by diazoxide and labetalol in hypertensive patients: preliminary findings. British Journal of Clinical Pharmacology, 8(Suppl 2), 195S-198S.
Pearson RM, et al. Comparison of Effects On Cerebral Blood Flow of Rapid Reduction in Systemic Arterial Pressure By Diazoxide and Labetalol in Hypertensive Patients: Preliminary Findings. Br J Clin Pharmacol. 1979;8(Suppl 2):195S-198S. PubMed PMID: 526401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of effects on cerebral blood flow of rapid reduction in systemic arterial pressure by diazoxide and labetalol in hypertensive patients: preliminary findings. AU - Pearson,R M, AU - Griffith,D N, AU - Woollard,M, AU - James,I M, AU - Havard,C W, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 195S EP - 198S JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 8 IS - Suppl 2 N2 - 1 Diazoxide 300 mg and labetalol 150 mg were each injected intravenously on separate occasions into five patients with essentail hypertension. The reduction in BP caused by labetalol was slightly greater than that produced by diazoxide. 2 In contrast the reduction in cerebral blood flow (CBF) by labetalol was not statistically significant, whereas diazoxide gave a greater and statistically significant reduction in CBF. 3 These observations suggest that labetalol may have an advantage over diazoxide for the rapid reduction in BP. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/526401/Comparison_of_effects_on_cerebral_blood_flow_of_rapid_reduction_in_systemic_arterial_pressure_by_diazoxide_and_labetalol_in_hypertensive_patients:_preliminary_findings_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0306-5251&date=1979&volume=8&issue=Suppl 2&spage=195S DB - PRIME DP - Unbound Medicine ER -