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In vitro and in vivo characteristics of some commercial phenobarbital tablets.
Int J Clin Pharmacol Biopharm. 1979 Dec; 17(12):492-7.IJ

Abstract

Using an incompletely randomized crossover study design, the oral bioavailability characteristics of 7 different brands of phenobarbital tablets, USP, 100 mg was investigated in 5 adult, male volunteers. From plasma drug concentration-time data, best estimates for the bioavailability parameters of peak plasma phenobarbital concentration (Cmax) and time to peak concentration (tmax) were obtained by curve fitting and area under the plasma drug concentration-time curve (AUC) computed with the trapezoid rule. No significant difference in Cmax or normalized AUC was seen for the 7 products investigated. Additionally, a difference in tmax was observed between 2 preparations (A and E) only (p less than or equal to 0.05). All drug products met USP requirements for weight variation and tablet disintegration and all but one product (D) exhibited reasonably good and similar dissolution characteristics in simulated gastric fluid. No correlation between various in vitro dissolution parameters and in vivo bioavailability of phenobarbital could be found for the 7 phenobarbital products studied.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

528095

Citation

Sylvestri, M F., and C T. Ueda. "In Vitro and in Vivo Characteristics of some Commercial Phenobarbital Tablets." International Journal of Clinical Pharmacology and Biopharmacy, vol. 17, no. 12, 1979, pp. 492-7.
Sylvestri MF, Ueda CT. In vitro and in vivo characteristics of some commercial phenobarbital tablets. Int J Clin Pharmacol Biopharm. 1979;17(12):492-7.
Sylvestri, M. F., & Ueda, C. T. (1979). In vitro and in vivo characteristics of some commercial phenobarbital tablets. International Journal of Clinical Pharmacology and Biopharmacy, 17(12), 492-7.
Sylvestri MF, Ueda CT. In Vitro and in Vivo Characteristics of some Commercial Phenobarbital Tablets. Int J Clin Pharmacol Biopharm. 1979;17(12):492-7. PubMed PMID: 528095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro and in vivo characteristics of some commercial phenobarbital tablets. AU - Sylvestri,M F, AU - Ueda,C T, PY - 1979/12/1/pubmed PY - 1979/12/1/medline PY - 1979/12/1/entrez SP - 492 EP - 7 JF - International journal of clinical pharmacology and biopharmacy JO - Int J Clin Pharmacol Biopharm VL - 17 IS - 12 N2 - Using an incompletely randomized crossover study design, the oral bioavailability characteristics of 7 different brands of phenobarbital tablets, USP, 100 mg was investigated in 5 adult, male volunteers. From plasma drug concentration-time data, best estimates for the bioavailability parameters of peak plasma phenobarbital concentration (Cmax) and time to peak concentration (tmax) were obtained by curve fitting and area under the plasma drug concentration-time curve (AUC) computed with the trapezoid rule. No significant difference in Cmax or normalized AUC was seen for the 7 products investigated. Additionally, a difference in tmax was observed between 2 preparations (A and E) only (p less than or equal to 0.05). All drug products met USP requirements for weight variation and tablet disintegration and all but one product (D) exhibited reasonably good and similar dissolution characteristics in simulated gastric fluid. No correlation between various in vitro dissolution parameters and in vivo bioavailability of phenobarbital could be found for the 7 phenobarbital products studied. SN - 0340-0026 UR - https://www.unboundmedicine.com/medline/citation/528095/In_vitro_and_in_vivo_characteristics_of_some_commercial_phenobarbital_tablets_ DB - PRIME DP - Unbound Medicine ER -
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