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Bowen's disease and 5-fluorouracil.
J Am Acad Dermatol. 1979 Dec; 1(6):513-22.JA

Abstract

Sixty-six confirmed cases of Bowen's disease (intraepidermal squamous cell carcinoma) were seen from 1965 through 1976: twenty-four cases were treated surgically-four by excision (two recurrences) and twenty by desiccation and curettage (four recurrences); one was treated with x-ray radiation; and forty-one were treated with topical 5-fluorouracil (5-FU) (three recurrences). Of the six surgical recurrences (25% recurrence), one was retreated by desiccation and curettage and five with 5-FU. Of the three recurrences after 5-FU (8% recurrence), all three were successfully retreated with 5-FU. In view of the generally high recurrence rate after all treatment modalities in Bowen's disease, related to both the ill-defined lateral margins and the frequent follicular involvement with the Bowen's process, prolonged treatment time is required for success with 5-FU. Treatment times employed were 4 to 12 weeks, with a median of 9 weeks. 5-FU concentration ranged from 1% to 3 % in propylene glycol. A 1% concentration of 5-FU was generally adequate on the face, except for occasional recalcitrant areas, such as the nose and eyebrow. A concentration of 2.5% to 3.0% was usually necessary for treatment of Bowen's disease on the other body areas.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

528700

Citation

Sturm, H M.. "Bowen's Disease and 5-fluorouracil." Journal of the American Academy of Dermatology, vol. 1, no. 6, 1979, pp. 513-22.
Sturm HM. Bowen's disease and 5-fluorouracil. J Am Acad Dermatol. 1979;1(6):513-22.
Sturm, H. M. (1979). Bowen's disease and 5-fluorouracil. Journal of the American Academy of Dermatology, 1(6), 513-22.
Sturm HM. Bowen's Disease and 5-fluorouracil. J Am Acad Dermatol. 1979;1(6):513-22. PubMed PMID: 528700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bowen's disease and 5-fluorouracil. A1 - Sturm,H M, PY - 1979/12/1/pubmed PY - 1979/12/1/medline PY - 1979/12/1/entrez SP - 513 EP - 22 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 1 IS - 6 N2 - Sixty-six confirmed cases of Bowen's disease (intraepidermal squamous cell carcinoma) were seen from 1965 through 1976: twenty-four cases were treated surgically-four by excision (two recurrences) and twenty by desiccation and curettage (four recurrences); one was treated with x-ray radiation; and forty-one were treated with topical 5-fluorouracil (5-FU) (three recurrences). Of the six surgical recurrences (25% recurrence), one was retreated by desiccation and curettage and five with 5-FU. Of the three recurrences after 5-FU (8% recurrence), all three were successfully retreated with 5-FU. In view of the generally high recurrence rate after all treatment modalities in Bowen's disease, related to both the ill-defined lateral margins and the frequent follicular involvement with the Bowen's process, prolonged treatment time is required for success with 5-FU. Treatment times employed were 4 to 12 weeks, with a median of 9 weeks. 5-FU concentration ranged from 1% to 3 % in propylene glycol. A 1% concentration of 5-FU was generally adequate on the face, except for occasional recalcitrant areas, such as the nose and eyebrow. A concentration of 2.5% to 3.0% was usually necessary for treatment of Bowen's disease on the other body areas. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/528700/Bowen's_disease_and_5_fluorouracil_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(79)80095-X DB - PRIME DP - Unbound Medicine ER -