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Functional subdivision of islets of Langerhans and possible role of D cells.
Lancet. 1975 Dec 20; 2(7947):1243-4.Lct

Abstract

Immunocytochemical examination of the islets of Langerhans in various animal species, including man, indicates that insulin-producing cells (B cells), glucagon-producing cells (A cells), and cells producing somatostatin or a somatostatin-like peptide (D cells) are not randomly arranged within the islet. Whenever A cells are found in the islet--i.e., mostly in its peripheral part--they are accompanied by D cells. However, most B cells, which occupy a central position, are in contact only with other B cells. In view of the inhibitory effect of somatostatin on both insulin and glucagon secretion, it is suggested that the arrangement of A, B and D cells is important to the normal and pathological functioning of the islet.

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Publisher Full Text

Authors

Orci L
No affiliation info available
Unger RH
No affiliation info available

MeSH

AnimalsGlucagonHumansInsulinInsulin AntagonistsInsulin SecretionIslets of LangerhansSomatostatin

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

53729

Citation

Orci, L, and R H. Unger. "Functional Subdivision of Islets of Langerhans and Possible Role of D Cells." Lancet (London, England), vol. 2, no. 7947, 1975, pp. 1243-4.
Orci L, Unger RH. Functional subdivision of islets of Langerhans and possible role of D cells. Lancet. 1975;2(7947):1243-4.
Orci, L., & Unger, R. H. (1975). Functional subdivision of islets of Langerhans and possible role of D cells. Lancet (London, England), 2(7947), 1243-4.
Orci L, Unger RH. Functional Subdivision of Islets of Langerhans and Possible Role of D Cells. Lancet. 1975 Dec 20;2(7947):1243-4. PubMed PMID: 53729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional subdivision of islets of Langerhans and possible role of D cells. AU - Orci,L, AU - Unger,R H, PY - 1975/12/20/pubmed PY - 1975/12/20/medline PY - 1975/12/20/entrez SP - 1243 EP - 4 JF - Lancet (London, England) JO - Lancet VL - 2 IS - 7947 N2 - Immunocytochemical examination of the islets of Langerhans in various animal species, including man, indicates that insulin-producing cells (B cells), glucagon-producing cells (A cells), and cells producing somatostatin or a somatostatin-like peptide (D cells) are not randomly arranged within the islet. Whenever A cells are found in the islet--i.e., mostly in its peripheral part--they are accompanied by D cells. However, most B cells, which occupy a central position, are in contact only with other B cells. In view of the inhibitory effect of somatostatin on both insulin and glucagon secretion, it is suggested that the arrangement of A, B and D cells is important to the normal and pathological functioning of the islet. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/53729/Functional_subdivision_of_islets_of_Langerhans_and_possible_role_of_D_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(75)92078-4 DB - PRIME DP - Unbound Medicine ER -