Tags

Type your tag names separated by a space and hit enter

[Subacute sclerosing panencephalitis. A case with a prolonged course in an adult. Isolation and characteristics of a "defective" measles virus (author's transl)].
Rev Neurol (Paris). 1979 Nov; 135(10):653-63.RN

Abstract

A 33-year-old man had a 6-year history of clinical signs suggesting multiple sclerosis : visual lesion at 27 years of age, cerebellar and visual disturbances at 31, which partly regressed, lymphocytosis and increased-gammaglobulin levels in the cerebrospinal fluid. Biological and anatomical (optical and ultrastructural) examinations gave results typical of a subacute sclerosing panencephalitis. A cytopathogenic measles virus was isolated from a cerebral biopsy specimen. The agent was transmissable to vero cells by co-culture but infectivity was always related to the cells and was therefore an incomplete viral infection. Virus-like particles were found in the nucleus and cytoplasm after electron microscopy examination of the co-cultures. Biochemical tests demonstrated that the viral proteins were all synthesized except hemagglutinin, which is a characterist abnormality of a "defective" measles virus.

Authors

Schott B
No affiliation info available
Chazot G
No affiliation info available
Dordain G
No affiliation info available
Kopp N
No affiliation info available
Laurent B
No affiliation info available
Wild TF
No affiliation info available

MeSH

AdultBrainDiagnosis, DifferentialHumansMaleMeasles virusMultiple SclerosisSubacute Sclerosing Panencephalitis

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

538383

Citation

Schott, B, et al. "[Subacute Sclerosing Panencephalitis. a Case With a Prolonged Course in an Adult. Isolation and Characteristics of a "defective" Measles Virus (author's Transl)]." Revue Neurologique, vol. 135, no. 10, 1979, pp. 653-63.
Schott B, Chazot G, Dordain G, et al. [Subacute sclerosing panencephalitis. A case with a prolonged course in an adult. Isolation and characteristics of a "defective" measles virus (author's transl)]. Rev Neurol (Paris). 1979;135(10):653-63.
Schott, B., Chazot, G., Dordain, G., Kopp, N., Laurent, B., & Wild, T. F. (1979). [Subacute sclerosing panencephalitis. A case with a prolonged course in an adult. Isolation and characteristics of a "defective" measles virus (author's transl)]. Revue Neurologique, 135(10), 653-63.
Schott B, et al. [Subacute Sclerosing Panencephalitis. a Case With a Prolonged Course in an Adult. Isolation and Characteristics of a "defective" Measles Virus (author's Transl)]. Rev Neurol (Paris). 1979;135(10):653-63. PubMed PMID: 538383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Subacute sclerosing panencephalitis. A case with a prolonged course in an adult. Isolation and characteristics of a "defective" measles virus (author's transl)]. AU - Schott,B, AU - Chazot,G, AU - Dordain,G, AU - Kopp,N, AU - Laurent,B, AU - Wild,T F, PY - 1979/11/1/pubmed PY - 1979/11/1/medline PY - 1979/11/1/entrez SP - 653 EP - 63 JF - Revue neurologique JO - Rev Neurol (Paris) VL - 135 IS - 10 N2 - A 33-year-old man had a 6-year history of clinical signs suggesting multiple sclerosis : visual lesion at 27 years of age, cerebellar and visual disturbances at 31, which partly regressed, lymphocytosis and increased-gammaglobulin levels in the cerebrospinal fluid. Biological and anatomical (optical and ultrastructural) examinations gave results typical of a subacute sclerosing panencephalitis. A cytopathogenic measles virus was isolated from a cerebral biopsy specimen. The agent was transmissable to vero cells by co-culture but infectivity was always related to the cells and was therefore an incomplete viral infection. Virus-like particles were found in the nucleus and cytoplasm after electron microscopy examination of the co-cultures. Biochemical tests demonstrated that the viral proteins were all synthesized except hemagglutinin, which is a characterist abnormality of a "defective" measles virus. SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/538383/[Subacute_sclerosing_panencephalitis__A_case_with_a_prolonged_course_in_an_adult__Isolation_and_characteristics_of_a_"defective"_measles_virus__author's_transl_]_ L2 - https://www.diseaseinfosearch.org/result/6907 DB - PRIME DP - Unbound Medicine ER -