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Diagnostic value of bone marrow culture in typhoid fever.
Trans R Soc Trop Med Hyg. 1979; 73(6):680-3.TR

Abstract

The diagnostic efficacy of bone-marrow culture, serial blood cultures and agglutination tests was compared in a prospective study of 60 patients with typhoid fever, two thirds of whom had received prior antibacterial therapy. Salmonella typhi was recovered from marrow cultures in 95% of patients but blood cultures were positive in only 43.3% (P less than 0.001). Agglutination tests were eventually diagnostic in 56.7% of patients, but in only 25% at the time of admission. If procedures had been limited to blood cultures and agglutination tests, diagnosis would have been missed in 21.7% of cases. The efficacy of marrow cultures was affected not by the duration of disease but by the extent of antibacterial therapy before presentation. Bacteriological recovery was faster from marrow cultures.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

538809

Citation

Guerra-Caceres, J G., et al. "Diagnostic Value of Bone Marrow Culture in Typhoid Fever." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 73, no. 6, 1979, pp. 680-3.
Guerra-Caceres JG, Gotuzzo-Herencia E, Crosby-Dagnino E, et al. Diagnostic value of bone marrow culture in typhoid fever. Trans R Soc Trop Med Hyg. 1979;73(6):680-3.
Guerra-Caceres, J. G., Gotuzzo-Herencia, E., Crosby-Dagnino, E., Miro-Quesada, M., & Carrillo-Parodi, C. (1979). Diagnostic value of bone marrow culture in typhoid fever. Transactions of the Royal Society of Tropical Medicine and Hygiene, 73(6), 680-3.
Guerra-Caceres JG, et al. Diagnostic Value of Bone Marrow Culture in Typhoid Fever. Trans R Soc Trop Med Hyg. 1979;73(6):680-3. PubMed PMID: 538809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic value of bone marrow culture in typhoid fever. AU - Guerra-Caceres,J G, AU - Gotuzzo-Herencia,E, AU - Crosby-Dagnino,E, AU - Miro-Quesada,M, AU - Carrillo-Parodi,C, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 680 EP - 3 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans. R. Soc. Trop. Med. Hyg. VL - 73 IS - 6 N2 - The diagnostic efficacy of bone-marrow culture, serial blood cultures and agglutination tests was compared in a prospective study of 60 patients with typhoid fever, two thirds of whom had received prior antibacterial therapy. Salmonella typhi was recovered from marrow cultures in 95% of patients but blood cultures were positive in only 43.3% (P less than 0.001). Agglutination tests were eventually diagnostic in 56.7% of patients, but in only 25% at the time of admission. If procedures had been limited to blood cultures and agglutination tests, diagnosis would have been missed in 21.7% of cases. The efficacy of marrow cultures was affected not by the duration of disease but by the extent of antibacterial therapy before presentation. Bacteriological recovery was faster from marrow cultures. SN - 0035-9203 UR - https://www.unboundmedicine.com/medline/citation/538809/Diagnostic_value_of_bone_marrow_culture_in_typhoid_fever_ L2 - https://academic.oup.com/trstmh/article-lookup/doi/10.1016/0035-9203(79)90020-8 DB - PRIME DP - Unbound Medicine ER -