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The immune response of the mouse to lymphocytic choriomeningitis virus. I. Circulating antibodies.
J Gen Virol. 1979 Dec; 45(3):703-10.JG

Abstract

A search was made in LCM virus-immune mice for virus-specific antibodies. With the help of an L-cell plaque assay, neutralizing antibody was readily detected. There were no essential differences between mouse strains, but marked differences existed between virus strains. Whereas the inoculation of either large or small doses of WE strain virus led to the early production of considerable concentrations of neutralizing antibody, in the case of E-350 strain virus, high doses were required and a much longer time interval had to elapse before the threshold of detection was attained. In addition to neutralizing antibody, LCM virus-infected mice produced sensitizing antibody (detected by the enhancing effect of an anti-mouse Ig antiserum on the ability of a serum to reduce virus infectivity) and complement-fixing antibody. Previous failures to detect neutralizing antibody in LCM virus-immune mice might have been caused by properties of the chosen virus, but in many instances lack of a suitable assay host is a more likely explanation.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

541676

Citation

Kimmig, B, and F Lehmann-Grube. "The Immune Response of the Mouse to Lymphocytic Choriomeningitis Virus. I. Circulating Antibodies." The Journal of General Virology, vol. 45, no. 3, 1979, pp. 703-10.
Kimmig B, Lehmann-Grube F. The immune response of the mouse to lymphocytic choriomeningitis virus. I. Circulating antibodies. J Gen Virol. 1979;45(3):703-10.
Kimmig, B., & Lehmann-Grube, F. (1979). The immune response of the mouse to lymphocytic choriomeningitis virus. I. Circulating antibodies. The Journal of General Virology, 45(3), 703-10.
Kimmig B, Lehmann-Grube F. The Immune Response of the Mouse to Lymphocytic Choriomeningitis Virus. I. Circulating Antibodies. J Gen Virol. 1979;45(3):703-10. PubMed PMID: 541676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The immune response of the mouse to lymphocytic choriomeningitis virus. I. Circulating antibodies. AU - Kimmig,B, AU - Lehmann-Grube,F, PY - 1979/12/1/pubmed PY - 1979/12/1/medline PY - 1979/12/1/entrez SP - 703 EP - 10 JF - The Journal of general virology JO - J Gen Virol VL - 45 IS - 3 N2 - A search was made in LCM virus-immune mice for virus-specific antibodies. With the help of an L-cell plaque assay, neutralizing antibody was readily detected. There were no essential differences between mouse strains, but marked differences existed between virus strains. Whereas the inoculation of either large or small doses of WE strain virus led to the early production of considerable concentrations of neutralizing antibody, in the case of E-350 strain virus, high doses were required and a much longer time interval had to elapse before the threshold of detection was attained. In addition to neutralizing antibody, LCM virus-infected mice produced sensitizing antibody (detected by the enhancing effect of an anti-mouse Ig antiserum on the ability of a serum to reduce virus infectivity) and complement-fixing antibody. Previous failures to detect neutralizing antibody in LCM virus-immune mice might have been caused by properties of the chosen virus, but in many instances lack of a suitable assay host is a more likely explanation. SN - 0022-1317 UR - https://www.unboundmedicine.com/medline/citation/541676/The_immune_response_of_the_mouse_to_lymphocytic_choriomeningitis_virus__I__Circulating_antibodies_ L2 - http://jgv.microbiologyresearch.org/pubmed/content/journal/jgv/10.1099/0022-1317-45-3-703 DB - PRIME DP - Unbound Medicine ER -