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Marihuana: studies on the disposition and metabolism of delta-9-tetrahydrocannabinol in man.
Science. 1970 Dec 18; 170(3964):1320-2.Sci

Abstract

Delta(9)-Tetrahydrocannabinol (the major active component of marihuana) administered intravenously to normal human volunteers persists in plasma for more than 3 days (t(1/2) = 56 hours). Its metabolites appear in plasma within 10 minutes after administration and persist along with the precursor compound. Delta(9)-Tetrahydrocannabinol is completely metabolized in man, and the radioactive metabolites are excreted in urine and feces for more than 8 days.

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Publisher Full Text

Authors

Lemberger L
No affiliation info available
Silberstein SD
No affiliation info available
Axelrod J
No affiliation info available
Kopin IJ
No affiliation info available

MeSH

AdultCannabisCarbon IsotopesChromatography, Thin LayerFecesFemaleHumansInjections, IntravenousMaleMetabolic Clearance RateTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

5479011

Citation

Lemberger, L, et al. "Marihuana: Studies On the Disposition and Metabolism of Delta-9-tetrahydrocannabinol in Man." Science (New York, N.Y.), vol. 170, no. 3964, 1970, pp. 1320-2.
Lemberger L, Silberstein SD, Axelrod J, et al. Marihuana: studies on the disposition and metabolism of delta-9-tetrahydrocannabinol in man. Science. 1970;170(3964):1320-2.
Lemberger, L., Silberstein, S. D., Axelrod, J., & Kopin, I. J. (1970). Marihuana: studies on the disposition and metabolism of delta-9-tetrahydrocannabinol in man. Science (New York, N.Y.), 170(3964), 1320-2.
Lemberger L, et al. Marihuana: Studies On the Disposition and Metabolism of Delta-9-tetrahydrocannabinol in Man. Science. 1970 Dec 18;170(3964):1320-2. PubMed PMID: 5479011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marihuana: studies on the disposition and metabolism of delta-9-tetrahydrocannabinol in man. AU - Lemberger,L, AU - Silberstein,S D, AU - Axelrod,J, AU - Kopin,I J, PY - 1970/12/18/pubmed PY - 1970/12/18/medline PY - 1970/12/18/entrez SP - 1320 EP - 2 JF - Science (New York, N.Y.) JO - Science VL - 170 IS - 3964 N2 - Delta(9)-Tetrahydrocannabinol (the major active component of marihuana) administered intravenously to normal human volunteers persists in plasma for more than 3 days (t(1/2) = 56 hours). Its metabolites appear in plasma within 10 minutes after administration and persist along with the precursor compound. Delta(9)-Tetrahydrocannabinol is completely metabolized in man, and the radioactive metabolites are excreted in urine and feces for more than 8 days. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/5479011/Marihuana:_studies_on_the_disposition_and_metabolism_of_delta_9_tetrahydrocannabinol_in_man_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=5479011 DB - PRIME DP - Unbound Medicine ER -