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The influence of phosphatidyl serine on the release of histamine from isolated rat mast cells induced by different agents.
Agents Actions. 1975 Oct; 5(4):296-301.AA

Abstract

The influence of phosphatidyl serine (PS) on histamine release from isolated rat mast cells induced by antigen, compound 48/80, adenosine-5'-triphosphate (ATP), the ionophore A23187, and decylamine was studied. PS enhanced antigen-induced release but inhibited the release caused by compound 48/80, A23187, and decylamine. PS did not influence the release induced by ATP. The different effects of PS on the action of the various histamine releasing agents do not conform to a unifying model for the action of PS on the release process. Possible interactions between PS and the agents in the incubation medium as well as at specific reactive sites on the plasma membrane might explain some of the effects of PS. Consequently, the results cannot be used as evidence for the existence of basic differences in the release process induced by various calcium- and energy-dependent releasing agents.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

55064

Citation

Grosman, N, and B Diamant. "The Influence of Phosphatidyl Serine On the Release of Histamine From Isolated Rat Mast Cells Induced By Different Agents." Agents and Actions, vol. 5, no. 4, 1975, pp. 296-301.
Grosman N, Diamant B. The influence of phosphatidyl serine on the release of histamine from isolated rat mast cells induced by different agents. Agents Actions. 1975;5(4):296-301.
Grosman, N., & Diamant, B. (1975). The influence of phosphatidyl serine on the release of histamine from isolated rat mast cells induced by different agents. Agents and Actions, 5(4), 296-301.
Grosman N, Diamant B. The Influence of Phosphatidyl Serine On the Release of Histamine From Isolated Rat Mast Cells Induced By Different Agents. Agents Actions. 1975;5(4):296-301. PubMed PMID: 55064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of phosphatidyl serine on the release of histamine from isolated rat mast cells induced by different agents. AU - Grosman,N, AU - Diamant,B, PY - 1975/10/1/pubmed PY - 1975/10/1/medline PY - 1975/10/1/entrez SP - 296 EP - 301 JF - Agents and actions JO - Agents Actions VL - 5 IS - 4 N2 - The influence of phosphatidyl serine (PS) on histamine release from isolated rat mast cells induced by antigen, compound 48/80, adenosine-5'-triphosphate (ATP), the ionophore A23187, and decylamine was studied. PS enhanced antigen-induced release but inhibited the release caused by compound 48/80, A23187, and decylamine. PS did not influence the release induced by ATP. The different effects of PS on the action of the various histamine releasing agents do not conform to a unifying model for the action of PS on the release process. Possible interactions between PS and the agents in the incubation medium as well as at specific reactive sites on the plasma membrane might explain some of the effects of PS. Consequently, the results cannot be used as evidence for the existence of basic differences in the release process induced by various calcium- and energy-dependent releasing agents. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/55064/The_influence_of_phosphatidyl_serine_on_the_release_of_histamine_from_isolated_rat_mast_cells_induced_by_different_agents_ DB - PRIME DP - Unbound Medicine ER -