Tags

Type your tag names separated by a space and hit enter

[Autoimmune aspermatogenetic orchiepididymitis in guinea pigs induced by water-soluble adjuvants].
Ann Immunol (Paris). 1977 Jan-Mar; 128(1-2):267-9.AI

Abstract

Use was made of water-soluble adjuvant fractions with homologous sperm, sperm extract or sperm autoantigens to induce autoimmune aspermatogenic orchiepididymitis (AIAO) in guinea-pigs. Guinea-pigs were injected with soluble sperm extract or sperm purified autoantigen S emulsified in incomplete Freund adjvant (IFA) together with two synthetic watersoluble adjuvants, Mur-Nac-L-Ala-D-isoGlu et Mur-Nac-L-Ala-acide D-isoGlu. These animals developed lesions of AIAO, delayed hypersensitivity reactions and specific anti-spermatozoa antibodies. These lesions and reactions were comparable to the ones induced in a control group treated with the same spermatozoa extract or autoantigen S in complet Freund adjuvants. No lesion was observed in the absence of IFA, Other guinea-pigs received a mixture of spermatoza or purified sperm autoantigens, S, P, T. and of polyadenylicpolyuridylic complex either in saline or emulsified in IFA. The recipients of sperm or autoantigen T mixed with Poly A:U, with ou without IFA, displayed lsdions of AIAO; autoantigen S and Poly A:U in IFA, provoked AIAO but did not do it in the absenceof IFA.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

557950

Citation

Toullet, F, et al. "[Autoimmune Aspermatogenetic Orchiepididymitis in Guinea Pigs Induced By Water-soluble Adjuvants]." Annales D'immunologie, vol. 128, no. 1-2, 1977, pp. 267-9.
Toullet F, Audibert F, Voisin GA, et al. [Autoimmune aspermatogenetic orchiepididymitis in guinea pigs induced by water-soluble adjuvants]. Ann Immunol (Paris). 1977;128(1-2):267-9.
Toullet, F., Audibert, F., Voisin, G. A., & Chedid, L. (1977). [Autoimmune aspermatogenetic orchiepididymitis in guinea pigs induced by water-soluble adjuvants]. Annales D'immunologie, 128(1-2), 267-9.
Toullet F, et al. [Autoimmune Aspermatogenetic Orchiepididymitis in Guinea Pigs Induced By Water-soluble Adjuvants]. Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):267-9. PubMed PMID: 557950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Autoimmune aspermatogenetic orchiepididymitis in guinea pigs induced by water-soluble adjuvants]. AU - Toullet,F, AU - Audibert,F, AU - Voisin,G A, AU - Chedid,L, PY - 1977/1/1/pubmed PY - 1977/1/1/medline PY - 1977/1/1/entrez SP - 267 EP - 9 JF - Annales d'immunologie JO - Ann Immunol (Paris) VL - 128 IS - 1-2 N2 - Use was made of water-soluble adjuvant fractions with homologous sperm, sperm extract or sperm autoantigens to induce autoimmune aspermatogenic orchiepididymitis (AIAO) in guinea-pigs. Guinea-pigs were injected with soluble sperm extract or sperm purified autoantigen S emulsified in incomplete Freund adjvant (IFA) together with two synthetic watersoluble adjuvants, Mur-Nac-L-Ala-D-isoGlu et Mur-Nac-L-Ala-acide D-isoGlu. These animals developed lesions of AIAO, delayed hypersensitivity reactions and specific anti-spermatozoa antibodies. These lesions and reactions were comparable to the ones induced in a control group treated with the same spermatozoa extract or autoantigen S in complet Freund adjuvants. No lesion was observed in the absence of IFA, Other guinea-pigs received a mixture of spermatoza or purified sperm autoantigens, S, P, T. and of polyadenylicpolyuridylic complex either in saline or emulsified in IFA. The recipients of sperm or autoantigen T mixed with Poly A:U, with ou without IFA, displayed lsdions of AIAO; autoantigen S and Poly A:U in IFA, provoked AIAO but did not do it in the absenceof IFA. SN - 0300-4910 UR - https://www.unboundmedicine.com/medline/citation/557950/[Autoimmune_aspermatogenetic_orchiepididymitis_in_guinea_pigs_induced_by_water_soluble_adjuvants]_ L2 - https://medlineplus.gov/autoimmunediseases.html DB - PRIME DP - Unbound Medicine ER -