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Immunoglobulins in human cervico-vaginal secretions.
Int Arch Allergy Appl Immunol. 1977; 53(5):402-8.IA

Abstract

The concentration of IgG, IgA and IgM has been measured in the cervico-vaginal secretions of 8 women with a normal menstrual cycle, 52 pregnant women, 6 post-menopausal women and 12 women with total hysterectomy. No significant difference in immunoglobulin levels was found in the cervico-vaginal secretions of women with a normal cycle as compared to those of post-menopausal or pregnant women. A significant decrease of the IgG/IgA ratio was noticed during ovulation as a consequence of increased IgA secretion. In patients with hysterectomy, the secretions are of vaginal origin only and contain negligible quantities of IgA. Secretory IgA is found essentially in the superior genital tract. IgM is present in trace amounts in all secretions and does not vary considerably. The secretion of immunoglobulins may be under hormonal control: in addition to ovarian hormones, corticosteroids seem also to be involved. The local application of a fluorinated corticosteroid into the vagina has produced a significant decrease of secretory IgA production. The therapeutic possibilities of administering a fluorinated corticosteroid in cases of sterility which are due to the production of anti-spermatozoal antibodies are discussed.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

558170

Citation

Jalanti, R, and H Isliker. "Immunoglobulins in Human Cervico-vaginal Secretions." International Archives of Allergy and Applied Immunology, vol. 53, no. 5, 1977, pp. 402-8.
Jalanti R, Isliker H. Immunoglobulins in human cervico-vaginal secretions. Int Arch Allergy Appl Immunol. 1977;53(5):402-8.
Jalanti, R., & Isliker, H. (1977). Immunoglobulins in human cervico-vaginal secretions. International Archives of Allergy and Applied Immunology, 53(5), 402-8.
Jalanti R, Isliker H. Immunoglobulins in Human Cervico-vaginal Secretions. Int Arch Allergy Appl Immunol. 1977;53(5):402-8. PubMed PMID: 558170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulins in human cervico-vaginal secretions. AU - Jalanti,R, AU - Isliker,H, PY - 1977/1/1/pubmed PY - 1977/1/1/medline PY - 1977/1/1/entrez KW - Biology KW - Cervix KW - Clinical Research KW - Genitalia KW - Genitalia, Female KW - Gynecologic Surgery KW - Hematological Effects KW - Hemic System KW - Hysterectomy KW - Immunoglobulin Alterations KW - Menopause KW - Menstrual Cycle KW - Menstruation KW - Physiology KW - Pregnancy KW - Reproduction KW - Research Methodology KW - Surgery KW - Treatment KW - Urogenital Surgery KW - Urogenital System KW - Uterus KW - Vagina SP - 402 EP - 8 JF - International archives of allergy and applied immunology JO - Int Arch Allergy Appl Immunol VL - 53 IS - 5 N2 - The concentration of IgG, IgA and IgM has been measured in the cervico-vaginal secretions of 8 women with a normal menstrual cycle, 52 pregnant women, 6 post-menopausal women and 12 women with total hysterectomy. No significant difference in immunoglobulin levels was found in the cervico-vaginal secretions of women with a normal cycle as compared to those of post-menopausal or pregnant women. A significant decrease of the IgG/IgA ratio was noticed during ovulation as a consequence of increased IgA secretion. In patients with hysterectomy, the secretions are of vaginal origin only and contain negligible quantities of IgA. Secretory IgA is found essentially in the superior genital tract. IgM is present in trace amounts in all secretions and does not vary considerably. The secretion of immunoglobulins may be under hormonal control: in addition to ovarian hormones, corticosteroids seem also to be involved. The local application of a fluorinated corticosteroid into the vagina has produced a significant decrease of secretory IgA production. The therapeutic possibilities of administering a fluorinated corticosteroid in cases of sterility which are due to the production of anti-spermatozoal antibodies are discussed. SN - 0020-5915 UR - https://www.unboundmedicine.com/medline/citation/558170/Immunoglobulins_in_human_cervico_vaginal_secretions_ DB - PRIME DP - Unbound Medicine ER -