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Vitamin B12 absorption studies: effect of parenteral non-radioactive B12 on serum level of 57CO vitamin B12.
J Clin Pathol. 1967 Sep; 20(5):687-8.JC

Abstract

The intestinal absorption of (57)Co vitamin B(12) has been measured by counting the radioactivity in the serum, and the effect of the parenteral administration of 1 mg. non-radioactive vitamin B(12) two hours after the oral dose has been studied. When parenteral vitamin B(12) was not given, the mean radioactivity in the serum was lower in both patients with pernicious anaemia and in control subjects, and the results in the patients with pernicious anaemia were more definitive. There was no significant difference between the results obtained with an Ekco scaler and those with an I.D.L. scaler. This is the simplest and most convenient method of measuring vitamin B(12) absorption. It is suggested that the test be standardized by giving 0.5 mug. (57)Co vitamin B(12) with a maximal histamine stimulation of intrinsic factor secretion, but without a parenteral dose of non-radioactive vitamin B(12). The results are expressed most usefully as a percentage of the administered dose per litre of serum or plasma.

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Authors

Harwood L
No affiliation info available
Forshaw J
No affiliation info available

MeSH

Anemia, PerniciousCobalt IsotopesHumansInjectionsIntestinal AbsorptionMethodsVitamin B 12

Pub Type(s)

Journal Article

Language

eng

PubMed ID

5602975

Citation

Harwood, L, and J Forshaw. "Vitamin B12 Absorption Studies: Effect of Parenteral Non-radioactive B12 On Serum Level of 57CO Vitamin B12." Journal of Clinical Pathology, vol. 20, no. 5, 1967, pp. 687-8.
Harwood L, Forshaw J. Vitamin B12 absorption studies: effect of parenteral non-radioactive B12 on serum level of 57CO vitamin B12. J Clin Pathol. 1967;20(5):687-8.
Harwood, L., & Forshaw, J. (1967). Vitamin B12 absorption studies: effect of parenteral non-radioactive B12 on serum level of 57CO vitamin B12. Journal of Clinical Pathology, 20(5), 687-8.
Harwood L, Forshaw J. Vitamin B12 Absorption Studies: Effect of Parenteral Non-radioactive B12 On Serum Level of 57CO Vitamin B12. J Clin Pathol. 1967;20(5):687-8. PubMed PMID: 5602975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B12 absorption studies: effect of parenteral non-radioactive B12 on serum level of 57CO vitamin B12. AU - Harwood,L, AU - Forshaw,J, PY - 1967/9/1/pubmed PY - 1967/9/1/medline PY - 1967/9/1/entrez SP - 687 EP - 8 JF - Journal of clinical pathology JO - J Clin Pathol VL - 20 IS - 5 N2 - The intestinal absorption of (57)Co vitamin B(12) has been measured by counting the radioactivity in the serum, and the effect of the parenteral administration of 1 mg. non-radioactive vitamin B(12) two hours after the oral dose has been studied. When parenteral vitamin B(12) was not given, the mean radioactivity in the serum was lower in both patients with pernicious anaemia and in control subjects, and the results in the patients with pernicious anaemia were more definitive. There was no significant difference between the results obtained with an Ekco scaler and those with an I.D.L. scaler. This is the simplest and most convenient method of measuring vitamin B(12) absorption. It is suggested that the test be standardized by giving 0.5 mug. (57)Co vitamin B(12) with a maximal histamine stimulation of intrinsic factor secretion, but without a parenteral dose of non-radioactive vitamin B(12). The results are expressed most usefully as a percentage of the administered dose per litre of serum or plasma. SN - 0021-9746 UR - https://www.unboundmedicine.com/medline/citation/5602975/Vitamin_B12_absorption_studies:_effect_of_parenteral_non_radioactive_B12_on_serum_level_of_57CO_vitamin_B12_ L2 - https://jcp.bmj.com/lookup/pmidlookup?view=long&pmid=5602975 DB - PRIME DP - Unbound Medicine ER -