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Progressive nerve lesion in a disease-arrested leprosy patient. An electron microscopic study.
Int J Lepr Other Mycobact Dis. 1977 Jul-Sep; 45(3):255-60.IJ

Abstract

An ulnar nerve biopsy from a patient with purely neural leprosy of the borderline tuberculoid group, who developed ulnar and median paralysis after 2.5 years of DDS therapy, was examined using light and electron microscopes. The nerve parenchyma was largely replaced by collagen fibrils. There were many onion bulbs similar to those seen in hypertrophic neuropathies. Bizarre fibroblasts such as those seen in hereditary sensory neuropathy were also demonstrated. A few Schwann cells contained M. leprae. It is suggested that considerable proliferation of fibrous tissue may be a reactive phenomenon in response to the continued presence of fragmented M. leprae and their products. Ischemia following a marked progressive increase of intraneural collagen is an important cause of atrophy of Schwann cells followed by segmental demyelination and necrosis of the axons in this healed leprosy patient.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

562856

Citation

Job, C K., et al. "Progressive Nerve Lesion in a Disease-arrested Leprosy Patient. an Electron Microscopic Study." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 45, no. 3, 1977, pp. 255-60.
Job CK, Victor DB, Chacko CJ. Progressive nerve lesion in a disease-arrested leprosy patient. An electron microscopic study. Int J Lepr Other Mycobact Dis. 1977;45(3):255-60.
Job, C. K., Victor, D. B., & Chacko, C. J. (1977). Progressive nerve lesion in a disease-arrested leprosy patient. An electron microscopic study. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 45(3), 255-60.
Job CK, Victor DB, Chacko CJ. Progressive Nerve Lesion in a Disease-arrested Leprosy Patient. an Electron Microscopic Study. Int J Lepr Other Mycobact Dis. 1977 Jul-Sep;45(3):255-60. PubMed PMID: 562856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progressive nerve lesion in a disease-arrested leprosy patient. An electron microscopic study. AU - Job,C K, AU - Victor,D B, AU - Chacko,C J, PY - 1977/7/1/pubmed PY - 1977/7/1/medline PY - 1977/7/1/entrez SP - 255 EP - 60 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 45 IS - 3 N2 - An ulnar nerve biopsy from a patient with purely neural leprosy of the borderline tuberculoid group, who developed ulnar and median paralysis after 2.5 years of DDS therapy, was examined using light and electron microscopes. The nerve parenchyma was largely replaced by collagen fibrils. There were many onion bulbs similar to those seen in hypertrophic neuropathies. Bizarre fibroblasts such as those seen in hereditary sensory neuropathy were also demonstrated. A few Schwann cells contained M. leprae. It is suggested that considerable proliferation of fibrous tissue may be a reactive phenomenon in response to the continued presence of fragmented M. leprae and their products. Ischemia following a marked progressive increase of intraneural collagen is an important cause of atrophy of Schwann cells followed by segmental demyelination and necrosis of the axons in this healed leprosy patient. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/562856/Progressive_nerve_lesion_in_a_disease_arrested_leprosy_patient__An_electron_microscopic_study_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -