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Lymphocytic choriomeningitis in laboratory personnel exposed to hamsters inadvertently infected with LCM virus.
J Am Vet Med Assoc. 1977 Nov 01; 171(9):829-32.JA

Abstract

Seven of 27 students and staff oa a university laboratory became ill with lymphocytic choriomeningitis (LCM) following exposure over an 18-month period to hamsters implanted with tumors. The clinical symptoms were compatible with LCM infection and all the patients' sera had fluorescent antibody to LCM virus; 5 of them also had complement-fixing (CF) antibodies. Complement-fixing antibodies were found in 9 of 9 hamsters with tumors and 16 of 31 without tumors (excluding 6 hamsters with anticomplementary sera) and in 8 of 14 rabbits, but in none of 49 rats. Lymphocytic choriomeningitis virus was isolated from 4 pools of liver and spleen, 2 each from hamsters with and without tumors, and from a frozen stored sample of the tumor cells. Interlaboratory transmission may have occurred via infected tumor cells. Control was achieved by destroying all animals in the project room as well as all hamsters in the building. The possibility that many tumor cell lines carried in hamsters may be infected with LCM virus has important implications for laboratory safety as well as for the validity of the research results obtained, inasmuch as the virus enhances the growth of some tumors and retards others.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

562868

Citation

Biggar, R J., et al. "Lymphocytic Choriomeningitis in Laboratory Personnel Exposed to Hamsters Inadvertently Infected With LCM Virus." Journal of the American Veterinary Medical Association, vol. 171, no. 9, 1977, pp. 829-32.
Biggar RJ, Schmidt TJ, Woodall JP. Lymphocytic choriomeningitis in laboratory personnel exposed to hamsters inadvertently infected with LCM virus. J Am Vet Med Assoc. 1977;171(9):829-32.
Biggar, R. J., Schmidt, T. J., & Woodall, J. P. (1977). Lymphocytic choriomeningitis in laboratory personnel exposed to hamsters inadvertently infected with LCM virus. Journal of the American Veterinary Medical Association, 171(9), 829-32.
Biggar RJ, Schmidt TJ, Woodall JP. Lymphocytic Choriomeningitis in Laboratory Personnel Exposed to Hamsters Inadvertently Infected With LCM Virus. J Am Vet Med Assoc. 1977 Nov 1;171(9):829-32. PubMed PMID: 562868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lymphocytic choriomeningitis in laboratory personnel exposed to hamsters inadvertently infected with LCM virus. AU - Biggar,R J, AU - Schmidt,T J, AU - Woodall,J P, PY - 1977/11/1/pubmed PY - 1977/11/1/medline PY - 1977/11/1/entrez SP - 829 EP - 32 JF - Journal of the American Veterinary Medical Association JO - J. Am. Vet. Med. Assoc. VL - 171 IS - 9 N2 - Seven of 27 students and staff oa a university laboratory became ill with lymphocytic choriomeningitis (LCM) following exposure over an 18-month period to hamsters implanted with tumors. The clinical symptoms were compatible with LCM infection and all the patients' sera had fluorescent antibody to LCM virus; 5 of them also had complement-fixing (CF) antibodies. Complement-fixing antibodies were found in 9 of 9 hamsters with tumors and 16 of 31 without tumors (excluding 6 hamsters with anticomplementary sera) and in 8 of 14 rabbits, but in none of 49 rats. Lymphocytic choriomeningitis virus was isolated from 4 pools of liver and spleen, 2 each from hamsters with and without tumors, and from a frozen stored sample of the tumor cells. Interlaboratory transmission may have occurred via infected tumor cells. Control was achieved by destroying all animals in the project room as well as all hamsters in the building. The possibility that many tumor cell lines carried in hamsters may be infected with LCM virus has important implications for laboratory safety as well as for the validity of the research results obtained, inasmuch as the virus enhances the growth of some tumors and retards others. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/562868/Lymphocytic_choriomeningitis_in_laboratory_personnel_exposed_to_hamsters_inadvertently_infected_with_LCM_virus_ DB - PRIME DP - Unbound Medicine ER -