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Behavioral effects of neuroleptics, apomorphine and amphetamine after bilateral lesion of the locus coeruleus in rats.
Pharmacol Biochem Behav 1977; 7(4):289-93PB

Abstract

Bilateral lesions of the locus coeruleus (LC) markedly increased susceptibility to the cateleptogenic effects of neuroleptics. The apomorphine-induced stereotypy was enhanced in rats with lesioned LC whilst amphetamine stereotypy was only slightly increased. No changes in locomotor activity have been observed in LC-lesioned rats treated with apomorphine and amphetamine. This data indicates that lesions of the LC produce decreased activity of dopaminergic brain neurons as well as supersensitivity of dopaminergic receptors.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

563082

Citation

Kostowski, W, et al. "Behavioral Effects of Neuroleptics, Apomorphine and Amphetamine After Bilateral Lesion of the Locus Coeruleus in Rats." Pharmacology, Biochemistry, and Behavior, vol. 7, no. 4, 1977, pp. 289-93.
Kostowski W, Jerlicz M, Bidzinski A, et al. Behavioral effects of neuroleptics, apomorphine and amphetamine after bilateral lesion of the locus coeruleus in rats. Pharmacol Biochem Behav. 1977;7(4):289-93.
Kostowski, W., Jerlicz, M., Bidzinski, A., & Hauptmann, M. (1977). Behavioral effects of neuroleptics, apomorphine and amphetamine after bilateral lesion of the locus coeruleus in rats. Pharmacology, Biochemistry, and Behavior, 7(4), pp. 289-93.
Kostowski W, et al. Behavioral Effects of Neuroleptics, Apomorphine and Amphetamine After Bilateral Lesion of the Locus Coeruleus in Rats. Pharmacol Biochem Behav. 1977;7(4):289-93. PubMed PMID: 563082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behavioral effects of neuroleptics, apomorphine and amphetamine after bilateral lesion of the locus coeruleus in rats. AU - Kostowski,W, AU - Jerlicz,M, AU - Bidzinski,A, AU - Hauptmann,M, PY - 1977/10/1/pubmed PY - 1977/10/1/medline PY - 1977/10/1/entrez SP - 289 EP - 93 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 7 IS - 4 N2 - Bilateral lesions of the locus coeruleus (LC) markedly increased susceptibility to the cateleptogenic effects of neuroleptics. The apomorphine-induced stereotypy was enhanced in rats with lesioned LC whilst amphetamine stereotypy was only slightly increased. No changes in locomotor activity have been observed in LC-lesioned rats treated with apomorphine and amphetamine. This data indicates that lesions of the LC produce decreased activity of dopaminergic brain neurons as well as supersensitivity of dopaminergic receptors. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/563082/Behavioral_effects_of_neuroleptics_apomorphine_and_amphetamine_after_bilateral_lesion_of_the_locus_coeruleus_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-3057(77)90222-2 DB - PRIME DP - Unbound Medicine ER -