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Time course of anoxia-induced K+ concentration changes in the cochlea measured with K+ specific microelectrodes.
Pflugers Arch. 1977; 372(3):207-13.PA

Abstract

The endocochlear potential (EP), potassium concentration in the endolymph (Ke+) and in the perilymph (Kp+) were measured in guinea-pigs during anoxia of different duration. Specific K+ double-barrel microelectrodes with liquid ion exchanger were used. The resting K+ concentration in the endolymph was 146.8 +/- 9.2 mM and in the perilymph 3.2 +/- 0.5 mM. The following time course of events was observed in the cochlea during anoxia: 40-50 s after the arrest of ventilation the K+ concentration decreased by 0.1-0.2 mM in the scala vestibuli, which was time related to a rapid fall of EP to negative values. Perilymphatic K+ started to increase in both scalae with a latency of 2-2.5 min, reaching a concentration of about 14 mM 60 min after the arrest of ventilation. The endolymphatic K+ began to decrease after a latency of 2.5-3 min, and 60 min after the arrest of ventilation an 80% concentration (average 112 mM K+) was reached as compared to the initial value. From the comparison of K+ concentration changes with the experimental values of the negative EP, it may be assumed that the negative EP is mainly generated by the K+ gradient between the perilymph and endolymph.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

564043

Citation

Melichar, I, and J Syka. "Time Course of Anoxia-induced K+ Concentration Changes in the Cochlea Measured With K+ Specific Microelectrodes." Pflugers Archiv : European Journal of Physiology, vol. 372, no. 3, 1977, pp. 207-13.
Melichar I, Syka J. Time course of anoxia-induced K+ concentration changes in the cochlea measured with K+ specific microelectrodes. Pflugers Arch. 1977;372(3):207-13.
Melichar, I., & Syka, J. (1977). Time course of anoxia-induced K+ concentration changes in the cochlea measured with K+ specific microelectrodes. Pflugers Archiv : European Journal of Physiology, 372(3), 207-13.
Melichar I, Syka J. Time Course of Anoxia-induced K+ Concentration Changes in the Cochlea Measured With K+ Specific Microelectrodes. Pflugers Arch. 1977;372(3):207-13. PubMed PMID: 564043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Time course of anoxia-induced K+ concentration changes in the cochlea measured with K+ specific microelectrodes. AU - Melichar,I, AU - Syka,J, PY - 1977/1/1/pubmed PY - 1977/1/1/medline PY - 1977/1/1/entrez SP - 207 EP - 13 JF - Pflugers Archiv : European journal of physiology JO - Pflugers Arch VL - 372 IS - 3 N2 - The endocochlear potential (EP), potassium concentration in the endolymph (Ke+) and in the perilymph (Kp+) were measured in guinea-pigs during anoxia of different duration. Specific K+ double-barrel microelectrodes with liquid ion exchanger were used. The resting K+ concentration in the endolymph was 146.8 +/- 9.2 mM and in the perilymph 3.2 +/- 0.5 mM. The following time course of events was observed in the cochlea during anoxia: 40-50 s after the arrest of ventilation the K+ concentration decreased by 0.1-0.2 mM in the scala vestibuli, which was time related to a rapid fall of EP to negative values. Perilymphatic K+ started to increase in both scalae with a latency of 2-2.5 min, reaching a concentration of about 14 mM 60 min after the arrest of ventilation. The endolymphatic K+ began to decrease after a latency of 2.5-3 min, and 60 min after the arrest of ventilation an 80% concentration (average 112 mM K+) was reached as compared to the initial value. From the comparison of K+ concentration changes with the experimental values of the negative EP, it may be assumed that the negative EP is mainly generated by the K+ gradient between the perilymph and endolymph. SN - 0031-6768 UR - https://www.unboundmedicine.com/medline/citation/564043/Time_course_of_anoxia_induced_K+_concentration_changes_in_the_cochlea_measured_with_K+_specific_microelectrodes_ L2 - https://medlineplus.gov/potassium.html DB - PRIME DP - Unbound Medicine ER -