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The significance of galactorrhea in patients with normal menses, oligomenorrhea, and secondary amenorrhea.
Am J Obstet Gynecol. 1978 Apr 15; 130(8):894-904.AJ

Abstract

Thyroid-stimulating hormone and prolactin (PRL) were measured in a group of 149 women with galactorrhea. Three of these patients were found to have primary hypothyroidism. In the remaining 146 patients, the PRL assay was correlated with the menstrual history and the results of hypocycloidal polytomography. Sixty-two per cent of these patients had hyperprolactinemia and 35 per cent had abnormal tomograms. Nine patients with abnormal x-rays had normal prolactin levels. None of the patients with normal menses and normal PRL was found to have an abnormal x-ray. Fourteen of the 15 patients with PRL levels greater than 200 ng. per milliliter had abnormal tomograms. Almost 70 per cent of patients with secondary amenorrhea and low estrogen status had abnormal x-rays. In patients with oligomenorrhea and secondary amenorrhea with normal estrogen status, it was not possible to differentiate between patients with normal or abnormal tomograms based on the level of serum PRL. Polytomography remains the single most important diagnostic test in establishing the presence of a pituitary tumor.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

565142

Citation

Davajan, V, et al. "The Significance of Galactorrhea in Patients With Normal Menses, Oligomenorrhea, and Secondary Amenorrhea." American Journal of Obstetrics and Gynecology, vol. 130, no. 8, 1978, pp. 894-904.
Davajan V, Kletzky O, March CM, et al. The significance of galactorrhea in patients with normal menses, oligomenorrhea, and secondary amenorrhea. Am J Obstet Gynecol. 1978;130(8):894-904.
Davajan, V., Kletzky, O., March, C. M., Roy, S., & Mishell, D. R. (1978). The significance of galactorrhea in patients with normal menses, oligomenorrhea, and secondary amenorrhea. American Journal of Obstetrics and Gynecology, 130(8), 894-904.
Davajan V, et al. The Significance of Galactorrhea in Patients With Normal Menses, Oligomenorrhea, and Secondary Amenorrhea. Am J Obstet Gynecol. 1978 Apr 15;130(8):894-904. PubMed PMID: 565142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The significance of galactorrhea in patients with normal menses, oligomenorrhea, and secondary amenorrhea. AU - Davajan,V, AU - Kletzky,O, AU - March,C M, AU - Roy,S, AU - Mishell,D R,Jr PY - 1978/4/15/pubmed PY - 2001/3/28/medline PY - 1978/4/15/entrez KW - Biology KW - Clinical Research KW - Conferences And Congresses KW - Diseases KW - Endocrine Effects KW - Endocrine System KW - Estrogens--analysis KW - Examinations And Diagnoses KW - Follicle Stimulating Hormone--analysis KW - Galactorrhea--etiology KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - Luteinizing Hormone KW - Menstruation KW - Menstruation Disorders KW - Oral Contraceptives KW - Physiology KW - Pituitary Hormone Releasing Hormones--analysis KW - Pituitary Hormones KW - Progestational Hormones KW - Progesterone--analysis KW - Prolactin--analysis KW - Puerperal Disorders KW - Reproduction KW - Research Methodology KW - Thyroid Effects SP - 894 EP - 904 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 130 IS - 8 N2 - Thyroid-stimulating hormone and prolactin (PRL) were measured in a group of 149 women with galactorrhea. Three of these patients were found to have primary hypothyroidism. In the remaining 146 patients, the PRL assay was correlated with the menstrual history and the results of hypocycloidal polytomography. Sixty-two per cent of these patients had hyperprolactinemia and 35 per cent had abnormal tomograms. Nine patients with abnormal x-rays had normal prolactin levels. None of the patients with normal menses and normal PRL was found to have an abnormal x-ray. Fourteen of the 15 patients with PRL levels greater than 200 ng. per milliliter had abnormal tomograms. Almost 70 per cent of patients with secondary amenorrhea and low estrogen status had abnormal x-rays. In patients with oligomenorrhea and secondary amenorrhea with normal estrogen status, it was not possible to differentiate between patients with normal or abnormal tomograms based on the level of serum PRL. Polytomography remains the single most important diagnostic test in establishing the presence of a pituitary tumor. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/565142/The_significance_of_galactorrhea_in_patients_with_normal_menses_oligomenorrhea_and_secondary_amenorrhea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9378(78)90266-1 DB - PRIME DP - Unbound Medicine ER -