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[Visceral kala-azar disease in a child (author's transl)].
Dtsch Med Wochenschr. 1978 Mar 10; 103(10):424-7.DM

Abstract

Repeated blood cultures were negative in a six-year-old boy with high septic temperature. Rheumatoid arthritis, typhoid and brucellosis were excluded. There was no evidence of leukaemia (bone-marrow tests). There was hepatomegaly with increased transaminase activity. Cortisone treatment was begun for suspected collagen disease. Several liver needle biopsies at first revelaed increasingly severe necrotising changes, predominantly in the centres of the acini. There were no parasites demonstrable histologically. The spleen was increased in the isotope scan but, covered by the liver, not definitely palpable. Diagnosis of mediterranean Kala-Azar disease was then suspected (the parents reporting a camping holiday in Yugoslavia) and finally proven serologically. The previously treatment-resistant disease improved dramatically after administration of trivalent antimony (Fuadin).

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Publisher Full Text

Authors

Löhr H
No affiliation info available
Wolf H
No affiliation info available

MeSH

Alanine TransaminaseAnimalsAntimonyArthritis, JuvenileAspartate AminotransferasesBrucellosis, BovineCattleChildDiagnosis, DifferentialHepatomegalyHumansLeishmaniasis, VisceralLeukemiaMaleTyphoid Fever

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

565281

Citation

Löhr, H, and H Wolf. "[Visceral Kala-azar Disease in a Child (author's Transl)]." Deutsche Medizinische Wochenschrift (1946), vol. 103, no. 10, 1978, pp. 424-7.
Löhr H, Wolf H. [Visceral kala-azar disease in a child (author's transl)]. Dtsch Med Wochenschr. 1978;103(10):424-7.
Löhr, H., & Wolf, H. (1978). [Visceral kala-azar disease in a child (author's transl)]. Deutsche Medizinische Wochenschrift (1946), 103(10), 424-7.
Löhr H, Wolf H. [Visceral Kala-azar Disease in a Child (author's Transl)]. Dtsch Med Wochenschr. 1978 Mar 10;103(10):424-7. PubMed PMID: 565281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Visceral kala-azar disease in a child (author's transl)]. AU - Löhr,H, AU - Wolf,H, PY - 1978/3/10/pubmed PY - 1978/3/10/medline PY - 1978/3/10/entrez SP - 424 EP - 7 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 103 IS - 10 N2 - Repeated blood cultures were negative in a six-year-old boy with high septic temperature. Rheumatoid arthritis, typhoid and brucellosis were excluded. There was no evidence of leukaemia (bone-marrow tests). There was hepatomegaly with increased transaminase activity. Cortisone treatment was begun for suspected collagen disease. Several liver needle biopsies at first revelaed increasingly severe necrotising changes, predominantly in the centres of the acini. There were no parasites demonstrable histologically. The spleen was increased in the isotope scan but, covered by the liver, not definitely palpable. Diagnosis of mediterranean Kala-Azar disease was then suspected (the parents reporting a camping holiday in Yugoslavia) and finally proven serologically. The previously treatment-resistant disease improved dramatically after administration of trivalent antimony (Fuadin). SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/565281/[Visceral_kala_azar_disease_in_a_child__author's_transl_]_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-0028-1104452 DB - PRIME DP - Unbound Medicine ER -