Tags

Type your tag names separated by a space and hit enter

Liver lesions in experimental lepromatoid leprosy of the armadillo. A histopathologic study.
Int J Lepr Other Mycobact Dis. 1978 Jan-Mar; 46(1):1-8.IJ

Abstract

A retrospective study of liver lesions was made in 13 armadillos infected intracutaneously with 10(7) M. leprae from the same inoculum, to evaluate the pathogenesis of the experimental disease. Survival times ranged from 13 to 55 months. In seven armadillos the liver lesions were markedly less severe than in six of these animals. The extent of the lesions was unrelated to the duration of the infection and was interpreted as reflecting individual differences in resistance. In contrast to man, leprosy bacilli were found in the liver cells of both groups of armadillos but to a lesser extent in those of the more resistant armadillos. The latter also had no obvious changes in the liver tissue except for round cell infiltration and prominent Kupffer's cells which contained M. leprae. These lesions can be compared to indeterminate leprosy in humans. The lesions in the more susceptible (lepromatoid) armadillos were initiated in Kupffer's cells. Later, large collections of bacillated macrophages infiltrated the liver lobules. The liver cells heavily loaded with M. leprae developed a pale granular cytoplasm which became foamy in the late lesions. In three of the lepromatoid livers, lesions compatible with erythema nodosum leprosum were seen.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

565751

Citation

Job, C K., et al. "Liver Lesions in Experimental Lepromatoid Leprosy of the Armadillo. a Histopathologic Study." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 46, no. 1, 1978, pp. 1-8.
Job CK, Kirchheimer WF, Sanchez RM. Liver lesions in experimental lepromatoid leprosy of the armadillo. A histopathologic study. Int J Lepr Other Mycobact Dis. 1978;46(1):1-8.
Job, C. K., Kirchheimer, W. F., & Sanchez, R. M. (1978). Liver lesions in experimental lepromatoid leprosy of the armadillo. A histopathologic study. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 46(1), 1-8.
Job CK, Kirchheimer WF, Sanchez RM. Liver Lesions in Experimental Lepromatoid Leprosy of the Armadillo. a Histopathologic Study. Int J Lepr Other Mycobact Dis. 1978 Jan-Mar;46(1):1-8. PubMed PMID: 565751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver lesions in experimental lepromatoid leprosy of the armadillo. A histopathologic study. AU - Job,C K, AU - Kirchheimer,W F, AU - Sanchez,R M, PY - 1978/1/1/pubmed PY - 1978/1/1/medline PY - 1978/1/1/entrez SP - 1 EP - 8 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 46 IS - 1 N2 - A retrospective study of liver lesions was made in 13 armadillos infected intracutaneously with 10(7) M. leprae from the same inoculum, to evaluate the pathogenesis of the experimental disease. Survival times ranged from 13 to 55 months. In seven armadillos the liver lesions were markedly less severe than in six of these animals. The extent of the lesions was unrelated to the duration of the infection and was interpreted as reflecting individual differences in resistance. In contrast to man, leprosy bacilli were found in the liver cells of both groups of armadillos but to a lesser extent in those of the more resistant armadillos. The latter also had no obvious changes in the liver tissue except for round cell infiltration and prominent Kupffer's cells which contained M. leprae. These lesions can be compared to indeterminate leprosy in humans. The lesions in the more susceptible (lepromatoid) armadillos were initiated in Kupffer's cells. Later, large collections of bacillated macrophages infiltrated the liver lobules. The liver cells heavily loaded with M. leprae developed a pale granular cytoplasm which became foamy in the late lesions. In three of the lepromatoid livers, lesions compatible with erythema nodosum leprosum were seen. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/565751/Liver_lesions_in_experimental_lepromatoid_leprosy_of_the_armadillo__A_histopathologic_study_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.