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Total and free triiodothyronine and thyroid-binding globulin concentration in elderly human persons.
Eur J Clin Invest. 1976 Mar 31; 6(2):139-45.EJ

Abstract

Total thyroxine (TT4) and triiodothyronine (TT3) were found to be low in healthy elderly subjects with a preferential decrease of triiodothyronine. In order to determine the importance of these findings 22 healthy elderly subjects were examined. Free triiodothyronine (FT3), thyroid binding globulin (TBG) concentration and basal thyroid stimulating hormone (TSH) were measured by radioimmunoassay. Liver enzymes, cholesterol and total protein concentration were also assayed. TBG was significantly increased compared to a middle-aged group and did not correlate with TT4, TT3 and TSH. Basal TSH values were in the normal range and could be detected in all the elderly subjects in contrast to undetectable values in 40% of the younger subjects. FT3 determined directly did not correlate with the values calculated according to the law of mass action. According to the FT3 values the elderly subjects could be subdivided into three groups independent of their TT4, TT3, TBG and TSH values. FT3 was undetectable in one group, in the low normal to normal range in another and elevated in the third group. Our results suggest that 1) there is no correlation between TT4, TT3, elevated TBG and FT3 determined directly or by calculation, 2) basal TSH values seem to indicate possible hypothyroidism in elderly persons which is correlated with elevated cholesterol levels and 3) FT3 measured directly subdivides this metabolic state into three groups possibly depending on the intracellular concentration of T4.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

57057

Citation

Hesch, R D., et al. "Total and Free Triiodothyronine and Thyroid-binding Globulin Concentration in Elderly Human Persons." European Journal of Clinical Investigation, vol. 6, no. 2, 1976, pp. 139-45.
Hesch RD, Gatz J, Pape J, et al. Total and free triiodothyronine and thyroid-binding globulin concentration in elderly human persons. Eur J Clin Invest. 1976;6(2):139-45.
Hesch, R. D., Gatz, J., Pape, J., Schmidt, E., & von zur Mühlen, A. (1976). Total and free triiodothyronine and thyroid-binding globulin concentration in elderly human persons. European Journal of Clinical Investigation, 6(2), 139-45.
Hesch RD, et al. Total and Free Triiodothyronine and Thyroid-binding Globulin Concentration in Elderly Human Persons. Eur J Clin Invest. 1976 Mar 31;6(2):139-45. PubMed PMID: 57057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Total and free triiodothyronine and thyroid-binding globulin concentration in elderly human persons. AU - Hesch,R D, AU - Gatz,J, AU - Pape,J, AU - Schmidt,E, AU - von zur Mühlen,A, PY - 1976/3/31/pubmed PY - 1976/3/31/medline PY - 1976/3/31/entrez SP - 139 EP - 45 JF - European journal of clinical investigation JO - Eur. J. Clin. Invest. VL - 6 IS - 2 N2 - Total thyroxine (TT4) and triiodothyronine (TT3) were found to be low in healthy elderly subjects with a preferential decrease of triiodothyronine. In order to determine the importance of these findings 22 healthy elderly subjects were examined. Free triiodothyronine (FT3), thyroid binding globulin (TBG) concentration and basal thyroid stimulating hormone (TSH) were measured by radioimmunoassay. Liver enzymes, cholesterol and total protein concentration were also assayed. TBG was significantly increased compared to a middle-aged group and did not correlate with TT4, TT3 and TSH. Basal TSH values were in the normal range and could be detected in all the elderly subjects in contrast to undetectable values in 40% of the younger subjects. FT3 determined directly did not correlate with the values calculated according to the law of mass action. According to the FT3 values the elderly subjects could be subdivided into three groups independent of their TT4, TT3, TBG and TSH values. FT3 was undetectable in one group, in the low normal to normal range in another and elevated in the third group. Our results suggest that 1) there is no correlation between TT4, TT3, elevated TBG and FT3 determined directly or by calculation, 2) basal TSH values seem to indicate possible hypothyroidism in elderly persons which is correlated with elevated cholesterol levels and 3) FT3 measured directly subdivides this metabolic state into three groups possibly depending on the intracellular concentration of T4. SN - 0014-2972 UR - https://www.unboundmedicine.com/medline/citation/57057/Total_and_free_triiodothyronine_and_thyroid_binding_globulin_concentration_in_elderly_human_persons_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0014-2972&date=1976&volume=6&issue=2&spage=139 DB - PRIME DP - Unbound Medicine ER -