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Failure of bromocriptine to suppress prolactin in majeptil-induced hyperprolactinemia.
Acta Eur Fertil. 1978 Dec; 9(4):185-8.AE

Abstract

A case of hyperprolactinemic anovulation with amenorrhea and galactorrhea, due to Phenothizine derivative (Majeptil) is presented. Treatment with bromocriptine, 2.5 mg b.i.d., p.o., or L-Dopa, 500 mg, p.o., did not suppress serum prolactin and menstrual cycle was not resumed. Pituitary prolactin response to TRH and Pituitary LH and FSH response to LHRH were found to be normal. It seems that at the dose used, bromocriptine (a dopaminergic agonist) cannot counteract the phenothiazine induced hyperprolactinemia. Hence, it is not effective in induction of ovulation while the patient is under phenothiazine treatment.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

573042

Citation

Yarkoni, S, et al. "Failure of Bromocriptine to Suppress Prolactin in Majeptil-induced Hyperprolactinemia." Acta Europaea Fertilitatis, vol. 9, no. 4, 1978, pp. 185-8.
Yarkoni S, Spitz IM, Ben-David M, et al. Failure of bromocriptine to suppress prolactin in majeptil-induced hyperprolactinemia. Acta Eur Fertil. 1978;9(4):185-8.
Yarkoni, S., Spitz, I. M., Ben-David, M., & Polishuk, W. Z. (1978). Failure of bromocriptine to suppress prolactin in majeptil-induced hyperprolactinemia. Acta Europaea Fertilitatis, 9(4), 185-8.
Yarkoni S, et al. Failure of Bromocriptine to Suppress Prolactin in Majeptil-induced Hyperprolactinemia. Acta Eur Fertil. 1978;9(4):185-8. PubMed PMID: 573042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Failure of bromocriptine to suppress prolactin in majeptil-induced hyperprolactinemia. AU - Yarkoni,S, AU - Spitz,I M, AU - Ben-David,M, AU - Polishuk,W Z, PY - 1978/12/1/pubmed PY - 1978/12/1/medline PY - 1978/12/1/entrez SP - 185 EP - 8 JF - Acta Europaea fertilitatis JO - Acta Eur Fertil VL - 9 IS - 4 N2 - A case of hyperprolactinemic anovulation with amenorrhea and galactorrhea, due to Phenothizine derivative (Majeptil) is presented. Treatment with bromocriptine, 2.5 mg b.i.d., p.o., or L-Dopa, 500 mg, p.o., did not suppress serum prolactin and menstrual cycle was not resumed. Pituitary prolactin response to TRH and Pituitary LH and FSH response to LHRH were found to be normal. It seems that at the dose used, bromocriptine (a dopaminergic agonist) cannot counteract the phenothiazine induced hyperprolactinemia. Hence, it is not effective in induction of ovulation while the patient is under phenothiazine treatment. SN - 0587-2421 UR - https://www.unboundmedicine.com/medline/citation/573042/Failure_of_bromocriptine_to_suppress_prolactin_in_majeptil_induced_hyperprolactinemia_ L2 - http://www.diseaseinfosearch.org/result/2971 DB - PRIME DP - Unbound Medicine ER -