Citation
Verhoeven, R P., et al. "Plasma Thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine During Beta-adrenergic Blockade in Hyperthyroidism." The Journal of Clinical Endocrinology and Metabolism, vol. 44, no. 5, 1977, pp. 1002-5.
Verhoeven RP, Visser TJ, Doctor R, et al. Plasma thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine during beta-adrenergic blockade in hyperthyroidism. J Clin Endocrinol Metab. 1977;44(5):1002-5.
Verhoeven, R. P., Visser, T. J., Doctor, R., Hennemann, G., & Schalekamp, M. A. (1977). Plasma thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine during beta-adrenergic blockade in hyperthyroidism. The Journal of Clinical Endocrinology and Metabolism, 44(5), 1002-5.
Verhoeven RP, et al. Plasma Thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine During Beta-adrenergic Blockade in Hyperthyroidism. J Clin Endocrinol Metab. 1977;44(5):1002-5. PubMed PMID: 576870.
TY - JOUR
T1 - Plasma thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine during beta-adrenergic blockade in hyperthyroidism.
AU - Verhoeven,R P,
AU - Visser,T J,
AU - Doctor,R,
AU - Hennemann,G,
AU - Schalekamp,M A,
PY - 1977/5/1/pubmed
PY - 1977/5/1/medline
PY - 1977/5/1/entrez
SP - 1002
EP - 5
JF - The Journal of clinical endocrinology and metabolism
JO - J Clin Endocrinol Metab
VL - 44
IS - 5
N2 - Plasma thyroxine (T4), 3,3',5-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) were measured in 16 patients with Graves' disease. Patients were studied under the following conditions: first without any treatment, then, during beta-adrenergic blockade with propranolol, and finally after euthyroidism had been attained by carbimazole. During propranolol T3/T4 ratio decreased, whereas T4 remained unchanged. After carbimazole T3/T4 ratio returned to its pretreatment value. rT3/T4 ratio showed opposite changes. These results suggest that peripheral conversion of T4 into T3 and rT3 in hyperthyroidism is, at least partly, dependent on the functional status of the beta-adrenergic system. Suppressed peripheral conversion of T4 into T3 during beta-adrenergic blocking agents may contribute to the beneficial effects of these drugs in thyrotoxicosis.
SN - 0021-972X
UR - https://www.unboundmedicine.com/medline/citation/576870/Plasma_thyroxine_33'5_triiodothyronine_and_33'5'_triiodothyronine_during_beta_adrenergic_blockade_in_hyperthyroidism_
L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-44-5-1002
DB - PRIME
DP - Unbound Medicine
ER -