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Plasma thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine during beta-adrenergic blockade in hyperthyroidism.
J Clin Endocrinol Metab. 1977 May; 44(5):1002-5.JC

Abstract

Plasma thyroxine (T4), 3,3',5-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) were measured in 16 patients with Graves' disease. Patients were studied under the following conditions: first without any treatment, then, during beta-adrenergic blockade with propranolol, and finally after euthyroidism had been attained by carbimazole. During propranolol T3/T4 ratio decreased, whereas T4 remained unchanged. After carbimazole T3/T4 ratio returned to its pretreatment value. rT3/T4 ratio showed opposite changes. These results suggest that peripheral conversion of T4 into T3 and rT3 in hyperthyroidism is, at least partly, dependent on the functional status of the beta-adrenergic system. Suppressed peripheral conversion of T4 into T3 during beta-adrenergic blocking agents may contribute to the beneficial effects of these drugs in thyrotoxicosis.

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Authors

Verhoeven RP
No affiliation info available
Visser TJ
No affiliation info available
Doctor R
No affiliation info available
Hennemann G
No affiliation info available
Schalekamp MA
No affiliation info available

MeSH

AdultAgedCarbimazoleFemaleGraves DiseaseHumansMaleMiddle AgedPropranololThyroxineTriiodothyronine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

576870

Citation

Verhoeven, R P., et al. "Plasma Thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine During Beta-adrenergic Blockade in Hyperthyroidism." The Journal of Clinical Endocrinology and Metabolism, vol. 44, no. 5, 1977, pp. 1002-5.
Verhoeven RP, Visser TJ, Doctor R, et al. Plasma thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine during beta-adrenergic blockade in hyperthyroidism. J Clin Endocrinol Metab. 1977;44(5):1002-5.
Verhoeven, R. P., Visser, T. J., Doctor, R., Hennemann, G., & Schalekamp, M. A. (1977). Plasma thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine during beta-adrenergic blockade in hyperthyroidism. The Journal of Clinical Endocrinology and Metabolism, 44(5), 1002-5.
Verhoeven RP, et al. Plasma Thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine During Beta-adrenergic Blockade in Hyperthyroidism. J Clin Endocrinol Metab. 1977;44(5):1002-5. PubMed PMID: 576870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine during beta-adrenergic blockade in hyperthyroidism. AU - Verhoeven,R P, AU - Visser,T J, AU - Doctor,R, AU - Hennemann,G, AU - Schalekamp,M A, PY - 1977/5/1/pubmed PY - 1977/5/1/medline PY - 1977/5/1/entrez SP - 1002 EP - 5 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 44 IS - 5 N2 - Plasma thyroxine (T4), 3,3',5-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) were measured in 16 patients with Graves' disease. Patients were studied under the following conditions: first without any treatment, then, during beta-adrenergic blockade with propranolol, and finally after euthyroidism had been attained by carbimazole. During propranolol T3/T4 ratio decreased, whereas T4 remained unchanged. After carbimazole T3/T4 ratio returned to its pretreatment value. rT3/T4 ratio showed opposite changes. These results suggest that peripheral conversion of T4 into T3 and rT3 in hyperthyroidism is, at least partly, dependent on the functional status of the beta-adrenergic system. Suppressed peripheral conversion of T4 into T3 during beta-adrenergic blocking agents may contribute to the beneficial effects of these drugs in thyrotoxicosis. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/576870/Plasma_thyroxine_33'5_triiodothyronine_and_33'5'_triiodothyronine_during_beta_adrenergic_blockade_in_hyperthyroidism_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-44-5-1002 DB - PRIME DP - Unbound Medicine ER -