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[Diagnosis and therapy of megaloblastic anemias].
Z Gesamte Inn Med. 1977 Sep 01; 32(17):425-31.ZG

Abstract

In most cases megaloblastic anaemias are the sequel of a deficiency of vitamin B12, more infrequently of a deficiency of folic acid of different etiology. Oriented to frequency and anamnesis the diagnostics follows the leading symptoms of pernicious anaemia (straw colour, glossitis, achlorhydria) and on the basis of special findings in the peripheral blood (hyperchromacia, megalocytosis, much decreased number of reticulocytes, increased iron and bilirubin level) it leads to the proved suspicion of a megaloblastic anaemia. This suspicion is ascertained by the investigation of the bone-marrow, with the help of aimed investigations the anaemia is further clarified differential-diagnostically. An unclear anaemia should not be treated ex juvantibus with vitamin B12 and/or folic acid. The therapy, always taking into consideration a possible basic disease, is carried out by parenteral application of vitamin B12, possibly in form of hydroxocobalamine or by folic acid. In persisting disturbance of the resorption of vitamin B12 on account of the threatening complication of a funicular spinal disease the long-term therapy must never be interrupted, unless in normal haematological findings.

Authors

Fischer H
No affiliation info available
Helbig W
No affiliation info available

MeSH

Anemia, MacrocyticAnemia, MegaloblasticAnemia, PerniciousDiagnosis, DifferentialHumansIntrinsic FactorVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

595705

Citation

Fischer, H, and W Helbig. "[Diagnosis and Therapy of Megaloblastic Anemias]." Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete, vol. 32, no. 17, 1977, pp. 425-31.
Fischer H, Helbig W. [Diagnosis and therapy of megaloblastic anemias]. Z Gesamte Inn Med. 1977;32(17):425-31.
Fischer, H., & Helbig, W. (1977). [Diagnosis and therapy of megaloblastic anemias]. Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete, 32(17), 425-31.
Fischer H, Helbig W. [Diagnosis and Therapy of Megaloblastic Anemias]. Z Gesamte Inn Med. 1977 Sep 1;32(17):425-31. PubMed PMID: 595705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diagnosis and therapy of megaloblastic anemias]. AU - Fischer,H, AU - Helbig,W, PY - 1977/9/1/pubmed PY - 1977/9/1/medline PY - 1977/9/1/entrez SP - 425 EP - 31 JF - Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete JO - Z Gesamte Inn Med VL - 32 IS - 17 N2 - In most cases megaloblastic anaemias are the sequel of a deficiency of vitamin B12, more infrequently of a deficiency of folic acid of different etiology. Oriented to frequency and anamnesis the diagnostics follows the leading symptoms of pernicious anaemia (straw colour, glossitis, achlorhydria) and on the basis of special findings in the peripheral blood (hyperchromacia, megalocytosis, much decreased number of reticulocytes, increased iron and bilirubin level) it leads to the proved suspicion of a megaloblastic anaemia. This suspicion is ascertained by the investigation of the bone-marrow, with the help of aimed investigations the anaemia is further clarified differential-diagnostically. An unclear anaemia should not be treated ex juvantibus with vitamin B12 and/or folic acid. The therapy, always taking into consideration a possible basic disease, is carried out by parenteral application of vitamin B12, possibly in form of hydroxocobalamine or by folic acid. In persisting disturbance of the resorption of vitamin B12 on account of the threatening complication of a funicular spinal disease the long-term therapy must never be interrupted, unless in normal haematological findings. SN - 0044-2542 UR - https://www.unboundmedicine.com/medline/citation/595705/[Diagnosis_and_therapy_of_megaloblastic_anemias]_ L2 - https://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -