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In vivo turnover rate of acetylcholine in rat brain parts at elevated steady-state concentration of plasma choline.
Acta Physiol Scand. 1977 Dec; 101(4):404-10.AP

Abstract

Cortical and striatal turnover rates of acetylcholine TR(ACh) were estimated by applying steady-state tracer kinetics in rats killed by microwave irradiation following a constant i.v. infusion of 3H-Ch. In control rats TR(ACh) was 3.6 nmol . g-1 . min-1 in the cortex and 23.8 nmol . g-1 . min-1 in the striatum. When steady-state plasma concentrations of Ch were increased from 17 to 140 mumol . 1-1 by a 15-min infusion of unlabelled Ch the corresponding TR(ACh) were 3.6 nmol . g-1 . min-1 and 21.4 nmol . g-1 . min-1, respectively. These results indicate that increased plasma levels of Ch are not accompanied by increased synthesis of brain ACh.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

596215

Citation

Eckernäs, S A., et al. "In Vivo Turnover Rate of Acetylcholine in Rat Brain Parts at Elevated Steady-state Concentration of Plasma Choline." Acta Physiologica Scandinavica, vol. 101, no. 4, 1977, pp. 404-10.
Eckernäs SA, Sahlström L, Aquilonius SM. In vivo turnover rate of acetylcholine in rat brain parts at elevated steady-state concentration of plasma choline. Acta Physiol Scand. 1977;101(4):404-10.
Eckernäs, S. A., Sahlström, L., & Aquilonius, S. M. (1977). In vivo turnover rate of acetylcholine in rat brain parts at elevated steady-state concentration of plasma choline. Acta Physiologica Scandinavica, 101(4), 404-10.
Eckernäs SA, Sahlström L, Aquilonius SM. In Vivo Turnover Rate of Acetylcholine in Rat Brain Parts at Elevated Steady-state Concentration of Plasma Choline. Acta Physiol Scand. 1977;101(4):404-10. PubMed PMID: 596215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo turnover rate of acetylcholine in rat brain parts at elevated steady-state concentration of plasma choline. AU - Eckernäs,S A, AU - Sahlström,L, AU - Aquilonius,S M, PY - 1977/12/1/pubmed PY - 1977/12/1/medline PY - 1977/12/1/entrez SP - 404 EP - 10 JF - Acta physiologica Scandinavica JO - Acta Physiol Scand VL - 101 IS - 4 N2 - Cortical and striatal turnover rates of acetylcholine TR(ACh) were estimated by applying steady-state tracer kinetics in rats killed by microwave irradiation following a constant i.v. infusion of 3H-Ch. In control rats TR(ACh) was 3.6 nmol . g-1 . min-1 in the cortex and 23.8 nmol . g-1 . min-1 in the striatum. When steady-state plasma concentrations of Ch were increased from 17 to 140 mumol . 1-1 by a 15-min infusion of unlabelled Ch the corresponding TR(ACh) were 3.6 nmol . g-1 . min-1 and 21.4 nmol . g-1 . min-1, respectively. These results indicate that increased plasma levels of Ch are not accompanied by increased synthesis of brain ACh. SN - 0001-6772 UR - https://www.unboundmedicine.com/medline/citation/596215/In_vivo_turnover_rate_of_acetylcholine_in_rat_brain_parts_at_elevated_steady_state_concentration_of_plasma_choline_ L2 - https://doi.org/10.1111/j.1748-1716.1977.tb06023.x DB - PRIME DP - Unbound Medicine ER -