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Prophylaxis and treatment of endemic goitre in Western Sudan with intramuscular iodized oil.
Ann Trop Paediatr 1984; 4(3):159-64AT

Abstract

A single injection of iodized oil was administered intramuscularly in a dose of 0.2-2 ml (475 mg iodine per ml) to 383 children from the villages of Kas and Dibbis of the Darfur region in Western Sudan, where goitre is prevalent. After one year the prevalence of goitre had declined from 76% to 49.6%. Of the goitrous children, 81.1% showed either complete resolution of goitre or definite regression of its size. None of the nongoitrous children developed goitre and none of the existing goitres became larger. No cases of hyper- or hypothyroidism were observed. The full 270 children were followed up for four-and-a-half years after treatment and compared with untreated controls from the same area. The prevalence of goitre was significantly lower in the treated than in the untreated group. In treated children the mean urinary iodine excretion three-and-a-half years after treatment was 188.7 micrograms/g creatinine. This was significantly higher than in the untreated group (P less than 0.001). One year later the mean urinary excretion of iodine in the treated children had decreased to 87.1 micrograms/g creatinine. There was no difference in the mean serum values of T3 and T4 in the treated and untreated groups. The level of thyroid stimulating hormone was significantly lower in the treated [mean (S.D.) = 3.5 (0.9)] than in the untreated children [6.0 (3.5)]. It is concluded that a single injection of iodized oil is safe and effective in prevention of goitre development, reduces goitre size and maintains a sufficient iodine supply to prevent goitre for at least four-and-a-half years in children from goitre-endemic areas in Western Sudan.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6084463

Citation

Abdel-Wahab, M M., et al. "Prophylaxis and Treatment of Endemic Goitre in Western Sudan With Intramuscular Iodized Oil." Annals of Tropical Paediatrics, vol. 4, no. 3, 1984, pp. 159-64.
Abdel-Wahab MM, Eltom M, Omer MI, et al. Prophylaxis and treatment of endemic goitre in Western Sudan with intramuscular iodized oil. Ann Trop Paediatr. 1984;4(3):159-64.
Abdel-Wahab, M. M., Eltom, M., Omer, M. I., Mukhtar, E., & Kaballo, A. M. (1984). Prophylaxis and treatment of endemic goitre in Western Sudan with intramuscular iodized oil. Annals of Tropical Paediatrics, 4(3), pp. 159-64.
Abdel-Wahab MM, et al. Prophylaxis and Treatment of Endemic Goitre in Western Sudan With Intramuscular Iodized Oil. Ann Trop Paediatr. 1984;4(3):159-64. PubMed PMID: 6084463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prophylaxis and treatment of endemic goitre in Western Sudan with intramuscular iodized oil. AU - Abdel-Wahab,M M, AU - Eltom,M, AU - Omer,M I, AU - Mukhtar,E, AU - Kaballo,A M, PY - 1984/9/1/pubmed PY - 1984/9/1/medline PY - 1984/9/1/entrez SP - 159 EP - 64 JF - Annals of tropical paediatrics JO - Ann Trop Paediatr VL - 4 IS - 3 N2 - A single injection of iodized oil was administered intramuscularly in a dose of 0.2-2 ml (475 mg iodine per ml) to 383 children from the villages of Kas and Dibbis of the Darfur region in Western Sudan, where goitre is prevalent. After one year the prevalence of goitre had declined from 76% to 49.6%. Of the goitrous children, 81.1% showed either complete resolution of goitre or definite regression of its size. None of the nongoitrous children developed goitre and none of the existing goitres became larger. No cases of hyper- or hypothyroidism were observed. The full 270 children were followed up for four-and-a-half years after treatment and compared with untreated controls from the same area. The prevalence of goitre was significantly lower in the treated than in the untreated group. In treated children the mean urinary iodine excretion three-and-a-half years after treatment was 188.7 micrograms/g creatinine. This was significantly higher than in the untreated group (P less than 0.001). One year later the mean urinary excretion of iodine in the treated children had decreased to 87.1 micrograms/g creatinine. There was no difference in the mean serum values of T3 and T4 in the treated and untreated groups. The level of thyroid stimulating hormone was significantly lower in the treated [mean (S.D.) = 3.5 (0.9)] than in the untreated children [6.0 (3.5)]. It is concluded that a single injection of iodized oil is safe and effective in prevention of goitre development, reduces goitre size and maintains a sufficient iodine supply to prevent goitre for at least four-and-a-half years in children from goitre-endemic areas in Western Sudan. SN - 0272-4936 UR - https://www.unboundmedicine.com/medline/citation/6084463/Prophylaxis_and_treatment_of_endemic_goitre_in_Western_Sudan_with_intramuscular_iodized_oil_ DB - PRIME DP - Unbound Medicine ER -