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The effect of H1 and H2 receptor blockers on immunological and nonspecific histamine release from isolated target cells.
Arch Immunol Ther Exp (Warsz). 1984; 32(5):599-604.AI

Abstract

The investigations were carried out on isolated peritoneal rat mast cells and human basophils. Cell histamine release was induced by a specific antigen, anti-IgE and by compound 48/80. Mepyramine and Diphenhydramine were used as H1 receptor blockers and Cimetidine as H2 receptor blocker. It was shown that effect of H1 and H2 receptor blockers on histamine release depends on concentration of drugs used in experiments, on the presence of exogenous histamine in the medium, on the kind of histamine liberators and also on the type of investigated target cells. The results obtained seem to indicate the presence of H2 receptors not only on basophils but also on mast cells.

Authors

Hofman J
No affiliation info available
Siergiejko Z
No affiliation info available
Kuczewska B
No affiliation info available
Chyrek-Borowska S
No affiliation info available

MeSH

AnimalsAntibodies, Anti-IdiotypicBasophilsCimetidineDiphenhydramineHistamine H1 AntagonistsHistamine H2 AntagonistsHistamine ReleaseImmunoglobulin EMast CellsRatsRats, Inbred Strains

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6085468

Citation

Hofman, J, et al. "The Effect of H1 and H2 Receptor Blockers On Immunological and Nonspecific Histamine Release From Isolated Target Cells." Archivum Immunologiae Et Therapiae Experimentalis, vol. 32, no. 5, 1984, pp. 599-604.
Hofman J, Siergiejko Z, Kuczewska B, et al. The effect of H1 and H2 receptor blockers on immunological and nonspecific histamine release from isolated target cells. Arch Immunol Ther Exp (Warsz). 1984;32(5):599-604.
Hofman, J., Siergiejko, Z., Kuczewska, B., & Chyrek-Borowska, S. (1984). The effect of H1 and H2 receptor blockers on immunological and nonspecific histamine release from isolated target cells. Archivum Immunologiae Et Therapiae Experimentalis, 32(5), 599-604.
Hofman J, et al. The Effect of H1 and H2 Receptor Blockers On Immunological and Nonspecific Histamine Release From Isolated Target Cells. Arch Immunol Ther Exp (Warsz). 1984;32(5):599-604. PubMed PMID: 6085468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of H1 and H2 receptor blockers on immunological and nonspecific histamine release from isolated target cells. AU - Hofman,J, AU - Siergiejko,Z, AU - Kuczewska,B, AU - Chyrek-Borowska,S, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 599 EP - 604 JF - Archivum immunologiae et therapiae experimentalis JO - Arch Immunol Ther Exp (Warsz) VL - 32 IS - 5 N2 - The investigations were carried out on isolated peritoneal rat mast cells and human basophils. Cell histamine release was induced by a specific antigen, anti-IgE and by compound 48/80. Mepyramine and Diphenhydramine were used as H1 receptor blockers and Cimetidine as H2 receptor blocker. It was shown that effect of H1 and H2 receptor blockers on histamine release depends on concentration of drugs used in experiments, on the presence of exogenous histamine in the medium, on the kind of histamine liberators and also on the type of investigated target cells. The results obtained seem to indicate the presence of H2 receptors not only on basophils but also on mast cells. SN - 0004-069X UR - https://www.unboundmedicine.com/medline/citation/6085468/The_effect_of_H1_and_H2_receptor_blockers_on_immunological_and_nonspecific_histamine_release_from_isolated_target_cells_ DB - PRIME DP - Unbound Medicine ER -