Tags

Type your tag names separated by a space and hit enter

Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors.
Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4922-5.PN

Abstract

Bronchial hyperresponsiveness to contractile agonists and nonspecific irritants is a characteristic feature of bronchial asthma. The mechanisms causing this hyperirritability are unknown. The existence of separate receptors for leukotrienes C4 and D4 (LTC4 and LTD4) has been demonstrated previously by physiologic and radioligand binding studies. The rank order of potency of the sulfidopeptide leukotrienes for contracting tracheal spirals [leukotriene E4 (LTE4) greater than LTD4 = LTC4] is different from that for contracting parenchymal strips (LTD4 greater than LTE4 greater than LTC4), thereby suggesting the existence of a separate receptor for LTE4. We now report that LTE4, the most stable of the leukotrienes comprising slow reacting substance of anaphylaxis, enhances the contractile response of guinea pig tracheal spirals but not of parenchymal strips to histamine in a time- and dose-dependent fashion. The ability of LTE4 to increase histamine responsiveness occurred after removal of the free agonist and recovery of the tissues to baseline tensions and was not produced by leukotrienes C4 and D4, which elicited the same magnitude of contraction of tracheal smooth muscle as LTE4. These findings suggest that LTE4-induced airway hyperirritability is not mediated by the contractile response per se and may be mediated through a receptor distinct from those for leukotrienes C4 and D4.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6087352

Citation

Lee, T H., et al. "Leukotriene E4-induced Airway Hyperresponsiveness of Guinea Pig Tracheal Smooth Muscle to Histamine and Evidence for Three Separate Sulfidopeptide Leukotriene Receptors." Proceedings of the National Academy of Sciences of the United States of America, vol. 81, no. 15, 1984, pp. 4922-5.
Lee TH, Austen KF, Corey EJ, et al. Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors. Proc Natl Acad Sci U S A. 1984;81(15):4922-5.
Lee, T. H., Austen, K. F., Corey, E. J., & Drazen, J. M. (1984). Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors. Proceedings of the National Academy of Sciences of the United States of America, 81(15), 4922-5.
Lee TH, et al. Leukotriene E4-induced Airway Hyperresponsiveness of Guinea Pig Tracheal Smooth Muscle to Histamine and Evidence for Three Separate Sulfidopeptide Leukotriene Receptors. Proc Natl Acad Sci U S A. 1984;81(15):4922-5. PubMed PMID: 6087352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors. AU - Lee,T H, AU - Austen,K F, AU - Corey,E J, AU - Drazen,J M, PY - 1984/8/1/pubmed PY - 1984/8/1/medline PY - 1984/8/1/entrez SP - 4922 EP - 5 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc Natl Acad Sci U S A VL - 81 IS - 15 N2 - Bronchial hyperresponsiveness to contractile agonists and nonspecific irritants is a characteristic feature of bronchial asthma. The mechanisms causing this hyperirritability are unknown. The existence of separate receptors for leukotrienes C4 and D4 (LTC4 and LTD4) has been demonstrated previously by physiologic and radioligand binding studies. The rank order of potency of the sulfidopeptide leukotrienes for contracting tracheal spirals [leukotriene E4 (LTE4) greater than LTD4 = LTC4] is different from that for contracting parenchymal strips (LTD4 greater than LTE4 greater than LTC4), thereby suggesting the existence of a separate receptor for LTE4. We now report that LTE4, the most stable of the leukotrienes comprising slow reacting substance of anaphylaxis, enhances the contractile response of guinea pig tracheal spirals but not of parenchymal strips to histamine in a time- and dose-dependent fashion. The ability of LTE4 to increase histamine responsiveness occurred after removal of the free agonist and recovery of the tissues to baseline tensions and was not produced by leukotrienes C4 and D4, which elicited the same magnitude of contraction of tracheal smooth muscle as LTE4. These findings suggest that LTE4-induced airway hyperirritability is not mediated by the contractile response per se and may be mediated through a receptor distinct from those for leukotrienes C4 and D4. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/6087352/Leukotriene_E4_induced_airway_hyperresponsiveness_of_guinea_pig_tracheal_smooth_muscle_to_histamine_and_evidence_for_three_separate_sulfidopeptide_leukotriene_receptors_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=6087352 DB - PRIME DP - Unbound Medicine ER -