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Pharmacological interaction of the effects of delta 9-trans-tetrahydrocannabinol and cannabidiol on serum corticosterone levels in rats.
Arch Int Pharmacodyn Ther 1984; 269(1):12-9AI

Abstract

The pharmacological interaction of the effects of delta 9-trans-tetrahydrocannabinol (delta 9-THC) and cannabidiol (CBD) on serum corticosterone levels in rats was studied in two experimental situations: simultaneous administration of the two cannabinoids, or administration of one followed by the other 24 hr later. Forty-five min after administration, both delta 9-THC (1, 2 and 4 mg/kg) and CBD (10, 30 and 60 mg/kg) induced a dose-dependent increase in corticosterone levels. The effect of the mixture delta 9-THC (2 mg/kg) with CBD (10, 30 and 60 mg/kg) did not differ significantly from that produced by CBD alone. We also observed that CBD (30 mg/kg), 24 hr after administration, potentiated the effect of delta 9-THC (2 mg/kg) even though it had no effect on corticosterone levels. This delayed interference of CBD with delta 9-THC effects was attributed to a pharmacokinetic interaction between the two cannabinoids.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6087750

Citation

Zuardi, A W., et al. "Pharmacological Interaction of the Effects of Delta 9-trans-tetrahydrocannabinol and Cannabidiol On Serum Corticosterone Levels in Rats." Archives Internationales De Pharmacodynamie Et De Therapie, vol. 269, no. 1, 1984, pp. 12-9.
Zuardi AW, Teixeira NA, Karniol IC. Pharmacological interaction of the effects of delta 9-trans-tetrahydrocannabinol and cannabidiol on serum corticosterone levels in rats. Arch Int Pharmacodyn Ther. 1984;269(1):12-9.
Zuardi, A. W., Teixeira, N. A., & Karniol, I. C. (1984). Pharmacological interaction of the effects of delta 9-trans-tetrahydrocannabinol and cannabidiol on serum corticosterone levels in rats. Archives Internationales De Pharmacodynamie Et De Therapie, 269(1), pp. 12-9.
Zuardi AW, Teixeira NA, Karniol IC. Pharmacological Interaction of the Effects of Delta 9-trans-tetrahydrocannabinol and Cannabidiol On Serum Corticosterone Levels in Rats. Arch Int Pharmacodyn Ther. 1984;269(1):12-9. PubMed PMID: 6087750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological interaction of the effects of delta 9-trans-tetrahydrocannabinol and cannabidiol on serum corticosterone levels in rats. AU - Zuardi,A W, AU - Teixeira,N A, AU - Karniol,I C, PY - 1984/5/1/pubmed PY - 1984/5/1/medline PY - 1984/5/1/entrez SP - 12 EP - 9 JF - Archives internationales de pharmacodynamie et de therapie JO - Arch Int Pharmacodyn Ther VL - 269 IS - 1 N2 - The pharmacological interaction of the effects of delta 9-trans-tetrahydrocannabinol (delta 9-THC) and cannabidiol (CBD) on serum corticosterone levels in rats was studied in two experimental situations: simultaneous administration of the two cannabinoids, or administration of one followed by the other 24 hr later. Forty-five min after administration, both delta 9-THC (1, 2 and 4 mg/kg) and CBD (10, 30 and 60 mg/kg) induced a dose-dependent increase in corticosterone levels. The effect of the mixture delta 9-THC (2 mg/kg) with CBD (10, 30 and 60 mg/kg) did not differ significantly from that produced by CBD alone. We also observed that CBD (30 mg/kg), 24 hr after administration, potentiated the effect of delta 9-THC (2 mg/kg) even though it had no effect on corticosterone levels. This delayed interference of CBD with delta 9-THC effects was attributed to a pharmacokinetic interaction between the two cannabinoids. SN - 0003-9780 UR - https://www.unboundmedicine.com/medline/citation/6087750/Pharmacological_interaction_of_the_effects_of_delta_9_trans_tetrahydrocannabinol_and_cannabidiol_on_serum_corticosterone_levels_in_rats_ DB - PRIME DP - Unbound Medicine ER -