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Acromegaly and Zollinger-Ellison syndrome secondary to an islet cell tumor: characterization and quantification of plasma and tumor human growth hormone-releasing factor.
J Clin Endocrinol Metab. 1984 Nov; 59(5):1002-5.JC

Abstract

A young woman with acromegaly and Zollinger-Ellison syndrome associated with a GH-releasing factor (GRF)- and gastrin-secreting metastatic islet cell carcinoma was studied by means of specific antisera which recognize various regions of the GRF molecule. Using specific immunohistochemical techniques, the tumor cells were shown to contain GRF, gastrin, and gastrin-releasing peptide, but not GH. During a 4-h period, plasma GRF levels averaged 5.6 +/- 1.4 ng/ml (+/- SD), while GH levels averaged 148 +/- 71 ng/ml. GH secretion was pulsatile and increased after TRH administration. GRF RIAs may be useful in establishing the diagnosis of acromegaly secondary to the ectopic secretion of GRF.

Authors

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Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6090497

Citation

Wilson, D M., et al. "Acromegaly and Zollinger-Ellison Syndrome Secondary to an Islet Cell Tumor: Characterization and Quantification of Plasma and Tumor Human Growth Hormone-releasing Factor." The Journal of Clinical Endocrinology and Metabolism, vol. 59, no. 5, 1984, pp. 1002-5.
Wilson DM, Ceda GP, Bostwick DG, et al. Acromegaly and Zollinger-Ellison syndrome secondary to an islet cell tumor: characterization and quantification of plasma and tumor human growth hormone-releasing factor. J Clin Endocrinol Metab. 1984;59(5):1002-5.
Wilson, D. M., Ceda, G. P., Bostwick, D. G., Webber, R. J., Minkoff, J. R., Pont, A., Hintz, R. L., Bensch, K. G., Kraemer, F. B., & Rosenfeld, R. G. (1984). Acromegaly and Zollinger-Ellison syndrome secondary to an islet cell tumor: characterization and quantification of plasma and tumor human growth hormone-releasing factor. The Journal of Clinical Endocrinology and Metabolism, 59(5), 1002-5.
Wilson DM, et al. Acromegaly and Zollinger-Ellison Syndrome Secondary to an Islet Cell Tumor: Characterization and Quantification of Plasma and Tumor Human Growth Hormone-releasing Factor. J Clin Endocrinol Metab. 1984;59(5):1002-5. PubMed PMID: 6090497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acromegaly and Zollinger-Ellison syndrome secondary to an islet cell tumor: characterization and quantification of plasma and tumor human growth hormone-releasing factor. A1 - Wilson,D M, AU - Ceda,G P, AU - Bostwick,D G, AU - Webber,R J, AU - Minkoff,J R, AU - Pont,A, AU - Hintz,R L, AU - Bensch,K G, AU - Kraemer,F B, AU - Rosenfeld,R G, PY - 1984/11/1/pubmed PY - 1984/11/1/medline PY - 1984/11/1/entrez SP - 1002 EP - 5 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 59 IS - 5 N2 - A young woman with acromegaly and Zollinger-Ellison syndrome associated with a GH-releasing factor (GRF)- and gastrin-secreting metastatic islet cell carcinoma was studied by means of specific antisera which recognize various regions of the GRF molecule. Using specific immunohistochemical techniques, the tumor cells were shown to contain GRF, gastrin, and gastrin-releasing peptide, but not GH. During a 4-h period, plasma GRF levels averaged 5.6 +/- 1.4 ng/ml (+/- SD), while GH levels averaged 148 +/- 71 ng/ml. GH secretion was pulsatile and increased after TRH administration. GRF RIAs may be useful in establishing the diagnosis of acromegaly secondary to the ectopic secretion of GRF. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/6090497/Acromegaly_and_Zollinger_Ellison_syndrome_secondary_to_an_islet_cell_tumor:_characterization_and_quantification_of_plasma_and_tumor_human_growth_hormone_releasing_factor_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-59-5-1002 DB - PRIME DP - Unbound Medicine ER -