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Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree--a new disease?
Clin Neuropathol. 1984 Sep-Oct; 3(5):185-92.CN

Abstract

The term Lewy body disease (LBD) was proposed earlier to describe a disease classified into three types (A, B, and C) according to the distributional pattern of Lewy bodies in the CNS. Group A (diffuse type of LBD) shows clinical symptoms of "dementia-parkinsonism syndrome". The most remarkable pathologic feature is the widespread appearance of numerous Lewy bodies not only in the brain stem and diencephalon (as in group C), but also in the cerebral cortex and basal ganglia, which is complicated by senile changes of various degrees. Group B is the transitional type between groups A and C. Group C (brain stem type of LBD) is identical with idiopathic Parkinson's disease. In this paper, 12 of our cases with diffuse type LBD were studied clinicopathologically and compared with eight similar cases in the literature. The neuropathologic substrate of progressive dementia in this disease is also discussed. LBD is a clinicopathologic entity; the diffuse type of LBD, a special form of this disease, presents mainly a presenile dementia.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6094067

Citation

Kosaka, K, et al. "Diffuse Type of Lewy Body Disease: Progressive Dementia With Abundant Cortical Lewy Bodies and Senile Changes of Varying Degree--a New Disease?" Clinical Neuropathology, vol. 3, no. 5, 1984, pp. 185-92.
Kosaka K, Yoshimura M, Ikeda K, et al. Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree--a new disease? Clin Neuropathol. 1984;3(5):185-92.
Kosaka, K., Yoshimura, M., Ikeda, K., & Budka, H. (1984). Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree--a new disease? Clinical Neuropathology, 3(5), 185-92.
Kosaka K, et al. Diffuse Type of Lewy Body Disease: Progressive Dementia With Abundant Cortical Lewy Bodies and Senile Changes of Varying Degree--a New Disease. Clin Neuropathol. 1984 Sep-Oct;3(5):185-92. PubMed PMID: 6094067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree--a new disease? AU - Kosaka,K, AU - Yoshimura,M, AU - Ikeda,K, AU - Budka,H, PY - 1984/9/1/pubmed PY - 1984/9/1/medline PY - 1984/9/1/entrez SP - 185 EP - 92 JF - Clinical neuropathology JO - Clin Neuropathol VL - 3 IS - 5 N2 - The term Lewy body disease (LBD) was proposed earlier to describe a disease classified into three types (A, B, and C) according to the distributional pattern of Lewy bodies in the CNS. Group A (diffuse type of LBD) shows clinical symptoms of "dementia-parkinsonism syndrome". The most remarkable pathologic feature is the widespread appearance of numerous Lewy bodies not only in the brain stem and diencephalon (as in group C), but also in the cerebral cortex and basal ganglia, which is complicated by senile changes of various degrees. Group B is the transitional type between groups A and C. Group C (brain stem type of LBD) is identical with idiopathic Parkinson's disease. In this paper, 12 of our cases with diffuse type LBD were studied clinicopathologically and compared with eight similar cases in the literature. The neuropathologic substrate of progressive dementia in this disease is also discussed. LBD is a clinicopathologic entity; the diffuse type of LBD, a special form of this disease, presents mainly a presenile dementia. SN - 0722-5091 UR - https://www.unboundmedicine.com/medline/citation/6094067/Diffuse_type_of_Lewy_body_disease:_progressive_dementia_with_abundant_cortical_Lewy_bodies_and_senile_changes_of_varying_degree__a_new_disease L2 - http://www.diseaseinfosearch.org/result/4215 DB - PRIME DP - Unbound Medicine ER -