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The guinea pig model for Argentine hemorrhagic fever.
Am J Trop Med Hyg. 1984 Nov; 33(6):1251-7.AJ

Abstract

Guinea pigs infected by the peripheral route with the XJ pathogenic strain of Junin virus showed viscerotropism mainly in reticulo-phagocytic rich organs. By immunofluorescence, heavy infection of reticular-phagocytic cells was demonstrated, supporting the leading role of these cell types. Absence of neurotropism was demonstrated by the inability to recover infectious virus, as well as the absence of antigens, immunoglobulins, or 3rd component of complement deposits, in cells, vessels, or meninges. The correlation between infectivity and antigen expression observed in organs, and the absence of evidence of immunopathologic mechanisms, strongly suggest a direct viral effect in these experimental conditions. The results show that infection of guinea pigs by the peripheral route is an adequate model for human Argentine hemorrhagic fever with the exception of central nervous system involvement. Comparisons are made with infections produced in guinea pigs by attenuated strains, as well as with the disease in primates and humans.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6095695

Citation

Oubiña, J R., et al. "The Guinea Pig Model for Argentine Hemorrhagic Fever." The American Journal of Tropical Medicine and Hygiene, vol. 33, no. 6, 1984, pp. 1251-7.
Oubiña JR, Carballal G, Videla CM, et al. The guinea pig model for Argentine hemorrhagic fever. Am J Trop Med Hyg. 1984;33(6):1251-7.
Oubiña, J. R., Carballal, G., Videla, C. M., & Cossio, P. M. (1984). The guinea pig model for Argentine hemorrhagic fever. The American Journal of Tropical Medicine and Hygiene, 33(6), 1251-7.
Oubiña JR, et al. The Guinea Pig Model for Argentine Hemorrhagic Fever. Am J Trop Med Hyg. 1984;33(6):1251-7. PubMed PMID: 6095695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The guinea pig model for Argentine hemorrhagic fever. AU - Oubiña,J R, AU - Carballal,G, AU - Videla,C M, AU - Cossio,P M, PY - 1984/11/1/pubmed PY - 1984/11/1/medline PY - 1984/11/1/entrez SP - 1251 EP - 7 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 33 IS - 6 N2 - Guinea pigs infected by the peripheral route with the XJ pathogenic strain of Junin virus showed viscerotropism mainly in reticulo-phagocytic rich organs. By immunofluorescence, heavy infection of reticular-phagocytic cells was demonstrated, supporting the leading role of these cell types. Absence of neurotropism was demonstrated by the inability to recover infectious virus, as well as the absence of antigens, immunoglobulins, or 3rd component of complement deposits, in cells, vessels, or meninges. The correlation between infectivity and antigen expression observed in organs, and the absence of evidence of immunopathologic mechanisms, strongly suggest a direct viral effect in these experimental conditions. The results show that infection of guinea pigs by the peripheral route is an adequate model for human Argentine hemorrhagic fever with the exception of central nervous system involvement. Comparisons are made with infections produced in guinea pigs by attenuated strains, as well as with the disease in primates and humans. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/6095695/The_guinea_pig_model_for_Argentine_hemorrhagic_fever_ DB - PRIME DP - Unbound Medicine ER -