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Evidence that cyclic AMP stimulates bacterial glycogen synthesis by relieving AMP inhibition of and by increasing the cellular level of ADP-glucose synthetase.
Arch Biochem Biophys. 1984 Dec; 235(2):493-503.AB

Abstract

Using Escherichia coli mutants that possess an ADP-glucose synthetase (EC 2.7.7.27, the rate-limiting enzyme of bacterial glycogen synthesis) that differs in its inhibition by physiological levels of AMP, evidence was obtained that cyclic AMP stimulates cellular glycogen synthesis during nitrogen starvation by relieving AMP inhibition of this enzyme (without altering the cellular AMP level). Deinhibition for AMP of an enzyme controlled by the adenylate energy charge allows selective release from this control despite the maintenance of a constant cellular energy charge value. It was also shown that an additional increase in rate, not accounted for by AMP deinhibition, was due to an increase in the cellular level of ADP-glucose synthetase.

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Authors

Leckie MP
No affiliation info available
Porter SE
No affiliation info available
Roth WG
No affiliation info available
Tieber VL
No affiliation info available
Dietzler DN
No affiliation info available

MeSH

Adenosine MonophosphateCyclic AMPEnzyme RepressionEscherichia coliGlucose-1-Phosphate AdenylyltransferaseGlycogenKineticsNucleotidyltransferases

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6097189

Citation

Leckie, M P., et al. "Evidence That Cyclic AMP Stimulates Bacterial Glycogen Synthesis By Relieving AMP Inhibition of and By Increasing the Cellular Level of ADP-glucose Synthetase." Archives of Biochemistry and Biophysics, vol. 235, no. 2, 1984, pp. 493-503.
Leckie MP, Porter SE, Roth WG, et al. Evidence that cyclic AMP stimulates bacterial glycogen synthesis by relieving AMP inhibition of and by increasing the cellular level of ADP-glucose synthetase. Arch Biochem Biophys. 1984;235(2):493-503.
Leckie, M. P., Porter, S. E., Roth, W. G., Tieber, V. L., & Dietzler, D. N. (1984). Evidence that cyclic AMP stimulates bacterial glycogen synthesis by relieving AMP inhibition of and by increasing the cellular level of ADP-glucose synthetase. Archives of Biochemistry and Biophysics, 235(2), 493-503.
Leckie MP, et al. Evidence That Cyclic AMP Stimulates Bacterial Glycogen Synthesis By Relieving AMP Inhibition of and By Increasing the Cellular Level of ADP-glucose Synthetase. Arch Biochem Biophys. 1984;235(2):493-503. PubMed PMID: 6097189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence that cyclic AMP stimulates bacterial glycogen synthesis by relieving AMP inhibition of and by increasing the cellular level of ADP-glucose synthetase. AU - Leckie,M P, AU - Porter,S E, AU - Roth,W G, AU - Tieber,V L, AU - Dietzler,D N, PY - 1984/12/1/pubmed PY - 1984/12/1/medline PY - 1984/12/1/entrez SP - 493 EP - 503 JF - Archives of biochemistry and biophysics JO - Arch Biochem Biophys VL - 235 IS - 2 N2 - Using Escherichia coli mutants that possess an ADP-glucose synthetase (EC 2.7.7.27, the rate-limiting enzyme of bacterial glycogen synthesis) that differs in its inhibition by physiological levels of AMP, evidence was obtained that cyclic AMP stimulates cellular glycogen synthesis during nitrogen starvation by relieving AMP inhibition of this enzyme (without altering the cellular AMP level). Deinhibition for AMP of an enzyme controlled by the adenylate energy charge allows selective release from this control despite the maintenance of a constant cellular energy charge value. It was also shown that an additional increase in rate, not accounted for by AMP deinhibition, was due to an increase in the cellular level of ADP-glucose synthetase. SN - 0003-9861 UR - https://www.unboundmedicine.com/medline/citation/6097189/Evidence_that_cyclic_AMP_stimulates_bacterial_glycogen_synthesis_by_relieving_AMP_inhibition_of_and_by_increasing_the_cellular_level_of_ADP_glucose_synthetase_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0003-9861(84)90222-4 DB - PRIME DP - Unbound Medicine ER -

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