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Alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of SHR during the onset of hypertension.
Biomed Biochim Acta. 1984; 43(8-9):S247-50.BB

Abstract

104 spontaneously hypertensive rats (SHR) and 107 normotensive control rats (WR) fed a commercial diet were sacrificed at 4, 8, 26 and 52 weeks of age. The kidneys were immediately removed and carefully separated into cortex and medulla. In general, the triglyceride levels in renal medulla appeared higher when compared with the cortex. On the other hand, phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were usually higher in the cortex and increased with age. In the kidneys of SHR at 8 weeks of age, i.e. during the development of hypertension, the percentage of linoleic acid (LA) in triglycerides and of arachidonic acid (AA) in PC was decreased. This was associated with an increase of AA in free fatty acids (FFA), indicating an enhanced activity of phospholipase A2. Furthermore, a fall of eicosapentaenoic acid (EPA) in triglycerides, FFA, PC and PE of kidneys in SHR at 8 weeks of age could be found. The data suggest that systematic alterations in the availability of individual polyunsaturated fatty acids in various renal lipids might be related to the onset of hypertension in SHR. Age-dependent changes in enzymes involved in prostaglandin formation should be considered as an adaptive mechanism which is insufficient to reduce or abolish genetically determined hypertension in SHR.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6097234

Citation

Singer, P, et al. "Alterations of Linoleic, Arachidonic and Eicosapentaenoic Acids in Renal Cortex and Medulla of SHR During the Onset of Hypertension." Biomedica Biochimica Acta, vol. 43, no. 8-9, 1984, pp. S247-50.
Singer P, Wirth M, Gerike U, et al. Alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of SHR during the onset of hypertension. Biomed Biochim Acta. 1984;43(8-9):S247-50.
Singer, P., Wirth, M., Gerike, U., Gödicke, W., & Moritz, V. (1984). Alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of SHR during the onset of hypertension. Biomedica Biochimica Acta, 43(8-9), S247-50.
Singer P, et al. Alterations of Linoleic, Arachidonic and Eicosapentaenoic Acids in Renal Cortex and Medulla of SHR During the Onset of Hypertension. Biomed Biochim Acta. 1984;43(8-9):S247-50. PubMed PMID: 6097234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of SHR during the onset of hypertension. AU - Singer,P, AU - Wirth,M, AU - Gerike,U, AU - Gödicke,W, AU - Moritz,V, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - S247 EP - 50 JF - Biomedica biochimica acta JO - Biomed Biochim Acta VL - 43 IS - 8-9 N2 - 104 spontaneously hypertensive rats (SHR) and 107 normotensive control rats (WR) fed a commercial diet were sacrificed at 4, 8, 26 and 52 weeks of age. The kidneys were immediately removed and carefully separated into cortex and medulla. In general, the triglyceride levels in renal medulla appeared higher when compared with the cortex. On the other hand, phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were usually higher in the cortex and increased with age. In the kidneys of SHR at 8 weeks of age, i.e. during the development of hypertension, the percentage of linoleic acid (LA) in triglycerides and of arachidonic acid (AA) in PC was decreased. This was associated with an increase of AA in free fatty acids (FFA), indicating an enhanced activity of phospholipase A2. Furthermore, a fall of eicosapentaenoic acid (EPA) in triglycerides, FFA, PC and PE of kidneys in SHR at 8 weeks of age could be found. The data suggest that systematic alterations in the availability of individual polyunsaturated fatty acids in various renal lipids might be related to the onset of hypertension in SHR. Age-dependent changes in enzymes involved in prostaglandin formation should be considered as an adaptive mechanism which is insufficient to reduce or abolish genetically determined hypertension in SHR. SN - 0232-766X UR - https://www.unboundmedicine.com/medline/citation/6097234/Alterations_of_linoleic_arachidonic_and_eicosapentaenoic_acids_in_renal_cortex_and_medulla_of_SHR_during_the_onset_of_hypertension_ DB - PRIME DP - Unbound Medicine ER -