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[Chemical composition of Brazilian marihuana samples and the importance of several constituents to the pharmacological activity of the plant].
Rev Bras Pesqui Med Biol. 1977 Dec; 10(6):379-85.RB

Abstract

The gas chromatographic analysis of marihuana samples seized by the São Paulo State Police showed high levels of delta9-trans-tetrahydrocannabinol (delta9-THC) the most active of cannabis constituents. The cannabiol (CBN) levels were also high and probably able of interfering with delta9-THC actions in some samples. The cannabidiol (CBD) and delta8-trans-tetrahydrocannabinol (delta8THC) levels were generally low. When compared to marihuanas used in other countries the amount of delta9-THC in our samples was in average higher. When the pharmacological activity of one of those marihuana extracts, called natural extract containing a high delta9-THC to the others cannabinoid ratio (CBD, CBN and delta8-THC) was compared to a synthetic extract with the same proportions of those cannabinoids, the activity was not identical in all animals tests used. The possibility of others substances present in the plant, besides those cannabinoids listed before, of interfering with the plant's pharmacological activity is discussed.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

por

PubMed ID

609775

Citation

Takahashi, R N., et al. "[Chemical Composition of Brazilian Marihuana Samples and the Importance of Several Constituents to the Pharmacological Activity of the Plant]." Revista Brasileira De Pesquisas Medicas E Biologicas, vol. 10, no. 6, 1977, pp. 379-85.
Takahashi RN, Zuardi AW, Karniol IG. [Chemical composition of Brazilian marihuana samples and the importance of several constituents to the pharmacological activity of the plant]. Rev Bras Pesqui Med Biol. 1977;10(6):379-85.
Takahashi, R. N., Zuardi, A. W., & Karniol, I. G. (1977). [Chemical composition of Brazilian marihuana samples and the importance of several constituents to the pharmacological activity of the plant]. Revista Brasileira De Pesquisas Medicas E Biologicas, 10(6), 379-85.
Takahashi RN, Zuardi AW, Karniol IG. [Chemical Composition of Brazilian Marihuana Samples and the Importance of Several Constituents to the Pharmacological Activity of the Plant]. Rev Bras Pesqui Med Biol. 1977;10(6):379-85. PubMed PMID: 609775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Chemical composition of Brazilian marihuana samples and the importance of several constituents to the pharmacological activity of the plant]. AU - Takahashi,R N, AU - Zuardi,A W, AU - Karniol,I G, PY - 1977/12/1/pubmed PY - 1977/12/1/medline PY - 1977/12/1/entrez SP - 379 EP - 85 JF - Revista brasileira de pesquisas medicas e biologicas JO - Rev Bras Pesqui Med Biol VL - 10 IS - 6 N2 - The gas chromatographic analysis of marihuana samples seized by the São Paulo State Police showed high levels of delta9-trans-tetrahydrocannabinol (delta9-THC) the most active of cannabis constituents. The cannabiol (CBN) levels were also high and probably able of interfering with delta9-THC actions in some samples. The cannabidiol (CBD) and delta8-trans-tetrahydrocannabinol (delta8THC) levels were generally low. When compared to marihuanas used in other countries the amount of delta9-THC in our samples was in average higher. When the pharmacological activity of one of those marihuana extracts, called natural extract containing a high delta9-THC to the others cannabinoid ratio (CBD, CBN and delta8-THC) was compared to a synthetic extract with the same proportions of those cannabinoids, the activity was not identical in all animals tests used. The possibility of others substances present in the plant, besides those cannabinoids listed before, of interfering with the plant's pharmacological activity is discussed. SN - 0034-7310 UR - https://www.unboundmedicine.com/medline/citation/609775/[Chemical_composition_of_Brazilian_marihuana_samples_and_the_importance_of_several_constituents_to_the_pharmacological_activity_of_the_plant]_ DB - PRIME DP - Unbound Medicine ER -