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[Infection of New World primates with Junín virus. IV. Aotus trivirgatus].
Rev Argent Microbiol. 1983; 15(4):219-22.RA

Abstract

Owl monkeys (Aotus trivirgatus) were inoculated with XJ, a pathogenic strain of Junin virus, seeking new animal models for Argentine Hemorrhagic Fever. Nine monkeys were inoculated intramuscularly with 30 or 300,000 TCID50 of junin virus. Hematological and virological studies showed no alteration in blood elements such as red cell, reticular cell and platelets, up to 28 days after inoculation. Hemoglobin and hematocrit determinations also remained constant. However, significant neutropenia was seen at day 11 and minimal viremia was detected in some animals during the second and third week post-inoculation. No clinical or behavioral modifications were observed during the eighty-days observation period. Non-specific necropsy findings included pyelonephritis, pneumonitis, liver abscess and eosinophilic spleen infiltrate. All of these findings seem to be unrelated to Junin virus inoculation. No virus was present in organs of animals killed 29, 57 or 85 days post-inoculation. All nine owl monkeys developed serum neutralizing antibodies by day 22. It is concluded that the owl monkey suffers a subclinical infection when inoculated with Junin virus, similar to that seen in other primate species (Saimiri sciureus and Alouatta caraya).

Authors+Show Affiliations

Cátedra de Microbiología, Parasitología e Inmunología, Facultad de Medicina, UNBA, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

6101070

Citation

Samoilovich, S R., et al. "[Infection of New World Primates With Junín Virus. IV. Aotus Trivirgatus]." Revista Argentina De Microbiologia, vol. 15, no. 4, 1983, pp. 219-22.
Samoilovich SR, Rondinone SN, Laguens RP, et al. [Infection of New World primates with Junín virus. IV. Aotus trivirgatus]. Rev Argent Microbiol. 1983;15(4):219-22.
Samoilovich, S. R., Rondinone, S. N., Laguens, R. P., Colillas, O., Frigerio, M. J., & Weissenbacher, M. C. (1983). [Infection of New World primates with Junín virus. IV. Aotus trivirgatus]. Revista Argentina De Microbiologia, 15(4), 219-22.
Samoilovich SR, et al. [Infection of New World Primates With Junín Virus. IV. Aotus Trivirgatus]. Rev Argent Microbiol. 1983;15(4):219-22. PubMed PMID: 6101070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Infection of New World primates with Junín virus. IV. Aotus trivirgatus]. AU - Samoilovich,S R, AU - Rondinone,S N, AU - Laguens,R P, AU - Colillas,O, AU - Frigerio,M J, AU - Weissenbacher,M C, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 219 EP - 22 JF - Revista Argentina de microbiologia JO - Rev Argent Microbiol VL - 15 IS - 4 N2 - Owl monkeys (Aotus trivirgatus) were inoculated with XJ, a pathogenic strain of Junin virus, seeking new animal models for Argentine Hemorrhagic Fever. Nine monkeys were inoculated intramuscularly with 30 or 300,000 TCID50 of junin virus. Hematological and virological studies showed no alteration in blood elements such as red cell, reticular cell and platelets, up to 28 days after inoculation. Hemoglobin and hematocrit determinations also remained constant. However, significant neutropenia was seen at day 11 and minimal viremia was detected in some animals during the second and third week post-inoculation. No clinical or behavioral modifications were observed during the eighty-days observation period. Non-specific necropsy findings included pyelonephritis, pneumonitis, liver abscess and eosinophilic spleen infiltrate. All of these findings seem to be unrelated to Junin virus inoculation. No virus was present in organs of animals killed 29, 57 or 85 days post-inoculation. All nine owl monkeys developed serum neutralizing antibodies by day 22. It is concluded that the owl monkey suffers a subclinical infection when inoculated with Junin virus, similar to that seen in other primate species (Saimiri sciureus and Alouatta caraya). SN - 0325-7541 UR - https://www.unboundmedicine.com/medline/citation/6101070/[Infection_of_New_World_primates_with_Junín_virus__IV__Aotus_trivirgatus]_ DB - PRIME DP - Unbound Medicine ER -