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Effect of the somatostatin analog D-Trp8,D-Cys14 on glucose insulin, pancreatic glucagon and growth hormone plasma levels in acromegalics and mild diabetics.
J Endocrinol Invest. 1980 Apr-Jun; 3(2):189-92.JE

Abstract

The effect of the somatostatin analog (GHRIH-A) D-Trp8, D-Cys14 on plasma levels of growth hormone, pancreatic glucagon, insulin and glucose was studied in four acromegalic patients and in four maturity-onset mild diabetics. Acromegalics received a bolus iv injection of 25 microgram of GHRIH-A, followed by a continuous infusion of 25 microgram in saline over an hour. Mild diabetics were submitted in two different days to two tests: arginine (30 g in 30 min) +/- GHRIH-A (bolus iv injection of 25 microgram followed by an infusion of 25 microgram/h over 120 min) and arginine + saline. GHRIH-A lead to a significant (2 p less than 0.01) fall in GH basal secretion in acromegalics, and significantly reduced the GH response to arginine in maturity-onset diabetics. The inhibitory effect of insulin secretion was less impressive, but significative in both groups. No significant changes in plasma pancreatic glucagon values were noted. In mild diabetics, GHRIH-A infusion induced a small but significant increase in the blood glucose increment due to arginine. Our data suggest that this somatostatin analog may be potentially useful only when GH suppression is the main therapeutic goal to be reached, as in acromegaly and in severe diabetic retinopathy, but not in metabolic control of mild diabetic patients with a good residual insulin secretion.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6104680

Citation

Trovati, M, et al. "Effect of the Somatostatin Analog D-Trp8,D-Cys14 On Glucose Insulin, Pancreatic Glucagon and Growth Hormone Plasma Levels in Acromegalics and Mild Diabetics." Journal of Endocrinological Investigation, vol. 3, no. 2, 1980, pp. 189-92.
Trovati M, Massara F, Camanni F, et al. Effect of the somatostatin analog D-Trp8,D-Cys14 on glucose insulin, pancreatic glucagon and growth hormone plasma levels in acromegalics and mild diabetics. J Endocrinol Invest. 1980;3(2):189-92.
Trovati, M., Massara, F., Camanni, F., Molinatti, G. M., Lorenzati, R., & Pagano, G. F. (1980). Effect of the somatostatin analog D-Trp8,D-Cys14 on glucose insulin, pancreatic glucagon and growth hormone plasma levels in acromegalics and mild diabetics. Journal of Endocrinological Investigation, 3(2), 189-92.
Trovati M, et al. Effect of the Somatostatin Analog D-Trp8,D-Cys14 On Glucose Insulin, Pancreatic Glucagon and Growth Hormone Plasma Levels in Acromegalics and Mild Diabetics. J Endocrinol Invest. 1980 Apr-Jun;3(2):189-92. PubMed PMID: 6104680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of the somatostatin analog D-Trp8,D-Cys14 on glucose insulin, pancreatic glucagon and growth hormone plasma levels in acromegalics and mild diabetics. AU - Trovati,M, AU - Massara,F, AU - Camanni,F, AU - Molinatti,G M, AU - Lorenzati,R, AU - Pagano,G F, PY - 1980/4/1/pubmed PY - 1980/4/1/medline PY - 1980/4/1/entrez SP - 189 EP - 92 JF - Journal of endocrinological investigation JO - J Endocrinol Invest VL - 3 IS - 2 N2 - The effect of the somatostatin analog (GHRIH-A) D-Trp8, D-Cys14 on plasma levels of growth hormone, pancreatic glucagon, insulin and glucose was studied in four acromegalic patients and in four maturity-onset mild diabetics. Acromegalics received a bolus iv injection of 25 microgram of GHRIH-A, followed by a continuous infusion of 25 microgram in saline over an hour. Mild diabetics were submitted in two different days to two tests: arginine (30 g in 30 min) +/- GHRIH-A (bolus iv injection of 25 microgram followed by an infusion of 25 microgram/h over 120 min) and arginine + saline. GHRIH-A lead to a significant (2 p less than 0.01) fall in GH basal secretion in acromegalics, and significantly reduced the GH response to arginine in maturity-onset diabetics. The inhibitory effect of insulin secretion was less impressive, but significative in both groups. No significant changes in plasma pancreatic glucagon values were noted. In mild diabetics, GHRIH-A infusion induced a small but significant increase in the blood glucose increment due to arginine. Our data suggest that this somatostatin analog may be potentially useful only when GH suppression is the main therapeutic goal to be reached, as in acromegaly and in severe diabetic retinopathy, but not in metabolic control of mild diabetic patients with a good residual insulin secretion. SN - 0391-4097 UR - https://www.unboundmedicine.com/medline/citation/6104680/Effect_of_the_somatostatin_analog_D_Trp8D_Cys14_on_glucose_insulin_pancreatic_glucagon_and_growth_hormone_plasma_levels_in_acromegalics_and_mild_diabetics_ L2 - https://link.springer.com/article/10.1007/BF03348250 DB - PRIME DP - Unbound Medicine ER -