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Selective effect of some somatostatin analogs on glucagon as opposed to insulin release in rats in vivo.
Metabolism. 1980 Aug; 29(8):728-31.M

Abstract

Cyclic somatostatin, at a dose of 700 but not 70 ng/kg/min, inhibited arginine-induced insulin and glucagon release as well as glucose stimulated insulin release in rats in vivo. Three somatostatin (S-S) analogs (D-Cys14-S-S, D-Trp8-D-Cys14-S-S and Ala2-D-Trp8-D-Cys14-S-S), at a dose of 70 ng/kg/min, suppressed arginine-induced glucagon but not insulin release. At the same dose, the first two of these analogs had no effect on glucose-induced insulin release, while the third one. Ala2-D-Trp8-D-Cys14-somatostatin, enhanced insulin release induced by glucose. A fourth analog, D-Trp8-somatostatin, was more potent than somatostatin with regard to arginine stimulated insulin and glucagon release, and equipotent with somatostatin with respect to glucose stimulated insulin release. These studies show, firstly, that the inhibitory effect of somatostatin analogs on arginine induced insulin release may be different from that when glucose is used as a stimulant and, secondly, that Ala2-D-Trp8-D-Cys14-somatostatin inhibits arginine-induced glucagon release while enhancing insulin release on glucose stimulation.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6105610

Citation

Lins, P E., et al. "Selective Effect of some Somatostatin Analogs On Glucagon as Opposed to Insulin Release in Rats in Vivo." Metabolism: Clinical and Experimental, vol. 29, no. 8, 1980, pp. 728-31.
Lins PE, Efendić S, Meyers CA, et al. Selective effect of some somatostatin analogs on glucagon as opposed to insulin release in rats in vivo. Metabolism. 1980;29(8):728-31.
Lins, P. E., Efendić, S., Meyers, C. A., Coy, D. H., Schally, A., & Luft, R. (1980). Selective effect of some somatostatin analogs on glucagon as opposed to insulin release in rats in vivo. Metabolism: Clinical and Experimental, 29(8), 728-31.
Lins PE, et al. Selective Effect of some Somatostatin Analogs On Glucagon as Opposed to Insulin Release in Rats in Vivo. Metabolism. 1980;29(8):728-31. PubMed PMID: 6105610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective effect of some somatostatin analogs on glucagon as opposed to insulin release in rats in vivo. AU - Lins,P E, AU - Efendić,S, AU - Meyers,C A, AU - Coy,D H, AU - Schally,A, AU - Luft,R, PY - 1980/8/1/pubmed PY - 1980/8/1/medline PY - 1980/8/1/entrez SP - 728 EP - 31 JF - Metabolism: clinical and experimental JO - Metabolism VL - 29 IS - 8 N2 - Cyclic somatostatin, at a dose of 700 but not 70 ng/kg/min, inhibited arginine-induced insulin and glucagon release as well as glucose stimulated insulin release in rats in vivo. Three somatostatin (S-S) analogs (D-Cys14-S-S, D-Trp8-D-Cys14-S-S and Ala2-D-Trp8-D-Cys14-S-S), at a dose of 70 ng/kg/min, suppressed arginine-induced glucagon but not insulin release. At the same dose, the first two of these analogs had no effect on glucose-induced insulin release, while the third one. Ala2-D-Trp8-D-Cys14-somatostatin, enhanced insulin release induced by glucose. A fourth analog, D-Trp8-somatostatin, was more potent than somatostatin with regard to arginine stimulated insulin and glucagon release, and equipotent with somatostatin with respect to glucose stimulated insulin release. These studies show, firstly, that the inhibitory effect of somatostatin analogs on arginine induced insulin release may be different from that when glucose is used as a stimulant and, secondly, that Ala2-D-Trp8-D-Cys14-somatostatin inhibits arginine-induced glucagon release while enhancing insulin release on glucose stimulation. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/6105610/Selective_effect_of_some_somatostatin_analogs_on_glucagon_as_opposed_to_insulin_release_in_rats_in_vivo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0026-0495(80)90194-8 DB - PRIME DP - Unbound Medicine ER -