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Effect of a somatostatin analog on insulin requirement and hormone levels in 6 insulin-dependent juvenile-onset diabetics subjected to artificial pancreas.
Acta Diabetol Lat. 1980 Jan-Mar; 17(1):9-14.AD

Abstract

This study was performed in order to investigate the effect of a 12-h infusion of the somatostatin selective analog D-Trp8, D-Cys14 Serono, (SRIF-A), on insuli requirement and C-peptide (CP), growth hormone (GH) and glucagon (IRG) levels in 6 insulin-dependent diabetics submitted to 60-h artificial pancreas (Biostator Miles) metabolic control from 2000 of the first day to 0800 of the fourth day. Meals were given at 1200 and 1700 of the second and third day. Before meals and 1-2 h after meals, plasma levels of CP, GH and IRG were measured. The two 12-h periods (midday-midnight) with and without continuous SRIF-A 12-h infusion (40 microgram/h) were considered. The SRIF-A infusion caused a 20% reduction in insulin requirement (p < 0.05) and a slight but significant reduction of GH levels (p < 0.05). CP and IRG were unaffected.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6106342

Citation

Lenti, G, et al. "Effect of a Somatostatin Analog On Insulin Requirement and Hormone Levels in 6 Insulin-dependent Juvenile-onset Diabetics Subjected to Artificial Pancreas." Acta Diabetologica Latina, vol. 17, no. 1, 1980, pp. 9-14.
Lenti G, Trovati M, Lorenzati R, et al. Effect of a somatostatin analog on insulin requirement and hormone levels in 6 insulin-dependent juvenile-onset diabetics subjected to artificial pancreas. Acta Diabetol Lat. 1980;17(1):9-14.
Lenti, G., Trovati, M., Lorenzati, R., Vitelli, F., Tagliaferro, V., Marocco, A., & Pagano, G. (1980). Effect of a somatostatin analog on insulin requirement and hormone levels in 6 insulin-dependent juvenile-onset diabetics subjected to artificial pancreas. Acta Diabetologica Latina, 17(1), 9-14.
Lenti G, et al. Effect of a Somatostatin Analog On Insulin Requirement and Hormone Levels in 6 Insulin-dependent Juvenile-onset Diabetics Subjected to Artificial Pancreas. Acta Diabetol Lat. 1980 Jan-Mar;17(1):9-14. PubMed PMID: 6106342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a somatostatin analog on insulin requirement and hormone levels in 6 insulin-dependent juvenile-onset diabetics subjected to artificial pancreas. AU - Lenti,G, AU - Trovati,M, AU - Lorenzati,R, AU - Vitelli,F, AU - Tagliaferro,V, AU - Marocco,A, AU - Pagano,G, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 9 EP - 14 JF - Acta diabetologica latina JO - Acta Diabetol Lat VL - 17 IS - 1 N2 - This study was performed in order to investigate the effect of a 12-h infusion of the somatostatin selective analog D-Trp8, D-Cys14 Serono, (SRIF-A), on insuli requirement and C-peptide (CP), growth hormone (GH) and glucagon (IRG) levels in 6 insulin-dependent diabetics submitted to 60-h artificial pancreas (Biostator Miles) metabolic control from 2000 of the first day to 0800 of the fourth day. Meals were given at 1200 and 1700 of the second and third day. Before meals and 1-2 h after meals, plasma levels of CP, GH and IRG were measured. The two 12-h periods (midday-midnight) with and without continuous SRIF-A 12-h infusion (40 microgram/h) were considered. The SRIF-A infusion caused a 20% reduction in insulin requirement (p < 0.05) and a slight but significant reduction of GH levels (p < 0.05). CP and IRG were unaffected. SN - 0001-5563 UR - https://www.unboundmedicine.com/medline/citation/6106342/Effect_of_a_somatostatin_analog_on_insulin_requirement_and_hormone_levels_in_6_insulin_dependent_juvenile_onset_diabetics_subjected_to_artificial_pancreas_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -