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Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin.
Am J Gastroenterol. 1980 Jul; 74(1):30-5.AJ

Abstract

An islet cell carcinoma of the pancreas is described in a 68-year old woman which clinically produced Zollinger-Ellison syndrome and, later in its course, Cushing syndrome. The tumor was found to contain gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin, by the immunoperoxidase technic. Electron microscopy revealed a single tumor cell type containing secretory granules of variable size, morphology and electron density. It appears that a single tumor cell population produced all five hormones and caused a transition in clinical symptomatology, while undergoing no change in morphology.

Authors

Asa SL
No affiliation info available
Kovacs K
No affiliation info available
Killinger DW
No affiliation info available
Marcon N
No affiliation info available
Platts M
No affiliation info available

MeSH

Adenoma, Islet CellAdrenocorticotropic HormoneAgedCalcitoninCushing SyndromeEndorphinsFemaleGastrinsHormones, EctopicHumansImmunoenzyme TechniquesPancreatic NeoplasmsParaneoplastic Endocrine SyndromesSomatostatinZollinger-Ellison Syndrome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6107042

Citation

Asa, S L., et al. "Pancreatic Islet Cell Carcinoma Producing Gastrin, ACTH, Alpha-endorphin, Somatostatin and Calcitonin." The American Journal of Gastroenterology, vol. 74, no. 1, 1980, pp. 30-5.
Asa SL, Kovacs K, Killinger DW, et al. Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin. Am J Gastroenterol. 1980;74(1):30-5.
Asa, S. L., Kovacs, K., Killinger, D. W., Marcon, N., & Platts, M. (1980). Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin. The American Journal of Gastroenterology, 74(1), 30-5.
Asa SL, et al. Pancreatic Islet Cell Carcinoma Producing Gastrin, ACTH, Alpha-endorphin, Somatostatin and Calcitonin. Am J Gastroenterol. 1980;74(1):30-5. PubMed PMID: 6107042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin. AU - Asa,S L, AU - Kovacs,K, AU - Killinger,D W, AU - Marcon,N, AU - Platts,M, PY - 1980/7/1/pubmed PY - 1980/7/1/medline PY - 1980/7/1/entrez SP - 30 EP - 5 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 74 IS - 1 N2 - An islet cell carcinoma of the pancreas is described in a 68-year old woman which clinically produced Zollinger-Ellison syndrome and, later in its course, Cushing syndrome. The tumor was found to contain gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin, by the immunoperoxidase technic. Electron microscopy revealed a single tumor cell type containing secretory granules of variable size, morphology and electron density. It appears that a single tumor cell population produced all five hormones and caused a transition in clinical symptomatology, while undergoing no change in morphology. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/6107042/Pancreatic_islet_cell_carcinoma_producing_gastrin_ACTH_alpha_endorphin_somatostatin_and_calcitonin_ L2 - https://medlineplus.gov/pancreaticcancer.html DB - PRIME DP - Unbound Medicine ER -