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Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin.
Am J Gastroenterol. 1980 Jul; 74(1):30-5.AJ

Abstract

An islet cell carcinoma of the pancreas is described in a 68-year old woman which clinically produced Zollinger-Ellison syndrome and, later in its course, Cushing syndrome. The tumor was found to contain gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin, by the immunoperoxidase technic. Electron microscopy revealed a single tumor cell type containing secretory granules of variable size, morphology and electron density. It appears that a single tumor cell population produced all five hormones and caused a transition in clinical symptomatology, while undergoing no change in morphology.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6107042

Citation

Asa, S L., et al. "Pancreatic Islet Cell Carcinoma Producing Gastrin, ACTH, Alpha-endorphin, Somatostatin and Calcitonin." The American Journal of Gastroenterology, vol. 74, no. 1, 1980, pp. 30-5.
Asa SL, Kovacs K, Killinger DW, et al. Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin. Am J Gastroenterol. 1980;74(1):30-5.
Asa, S. L., Kovacs, K., Killinger, D. W., Marcon, N., & Platts, M. (1980). Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin. The American Journal of Gastroenterology, 74(1), 30-5.
Asa SL, et al. Pancreatic Islet Cell Carcinoma Producing Gastrin, ACTH, Alpha-endorphin, Somatostatin and Calcitonin. Am J Gastroenterol. 1980;74(1):30-5. PubMed PMID: 6107042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin. AU - Asa,S L, AU - Kovacs,K, AU - Killinger,D W, AU - Marcon,N, AU - Platts,M, PY - 1980/7/1/pubmed PY - 1980/7/1/medline PY - 1980/7/1/entrez SP - 30 EP - 5 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 74 IS - 1 N2 - An islet cell carcinoma of the pancreas is described in a 68-year old woman which clinically produced Zollinger-Ellison syndrome and, later in its course, Cushing syndrome. The tumor was found to contain gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin, by the immunoperoxidase technic. Electron microscopy revealed a single tumor cell type containing secretory granules of variable size, morphology and electron density. It appears that a single tumor cell population produced all five hormones and caused a transition in clinical symptomatology, while undergoing no change in morphology. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/6107042/Pancreatic_islet_cell_carcinoma_producing_gastrin_ACTH_alpha_endorphin_somatostatin_and_calcitonin_ L2 - https://medlineplus.gov/pancreaticcancer.html DB - PRIME DP - Unbound Medicine ER -