Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin.Am J Gastroenterol. 1980 Jul; 74(1):30-5.AJ
Abstract
An islet cell carcinoma of the pancreas is described in a 68-year old woman which clinically produced Zollinger-Ellison syndrome and, later in its course, Cushing syndrome. The tumor was found to contain gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin, by the immunoperoxidase technic. Electron microscopy revealed a single tumor cell type containing secretory granules of variable size, morphology and electron density. It appears that a single tumor cell population produced all five hormones and caused a transition in clinical symptomatology, while undergoing no change in morphology.
MeSH
Pub Type(s)
Case Reports
Journal Article
Language
eng
PubMed ID
6107042
Citation
Asa, S L., et al. "Pancreatic Islet Cell Carcinoma Producing Gastrin, ACTH, Alpha-endorphin, Somatostatin and Calcitonin." The American Journal of Gastroenterology, vol. 74, no. 1, 1980, pp. 30-5.
Asa SL, Kovacs K, Killinger DW, et al. Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin. Am J Gastroenterol. 1980;74(1):30-5.
Asa, S. L., Kovacs, K., Killinger, D. W., Marcon, N., & Platts, M. (1980). Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin. The American Journal of Gastroenterology, 74(1), 30-5.
Asa SL, et al. Pancreatic Islet Cell Carcinoma Producing Gastrin, ACTH, Alpha-endorphin, Somatostatin and Calcitonin. Am J Gastroenterol. 1980;74(1):30-5. PubMed PMID: 6107042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin.
AU - Asa,S L,
AU - Kovacs,K,
AU - Killinger,D W,
AU - Marcon,N,
AU - Platts,M,
PY - 1980/7/1/pubmed
PY - 1980/7/1/medline
PY - 1980/7/1/entrez
SP - 30
EP - 5
JF - The American journal of gastroenterology
JO - Am J Gastroenterol
VL - 74
IS - 1
N2 - An islet cell carcinoma of the pancreas is described in a 68-year old woman which clinically produced Zollinger-Ellison syndrome and, later in its course, Cushing syndrome. The tumor was found to contain gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin, by the immunoperoxidase technic. Electron microscopy revealed a single tumor cell type containing secretory granules of variable size, morphology and electron density. It appears that a single tumor cell population produced all five hormones and caused a transition in clinical symptomatology, while undergoing no change in morphology.
SN - 0002-9270
UR - https://www.unboundmedicine.com/medline/citation/6107042/Pancreatic_islet_cell_carcinoma_producing_gastrin_ACTH_alpha_endorphin_somatostatin_and_calcitonin_
L2 - https://medlineplus.gov/pancreaticcancer.html
DB - PRIME
DP - Unbound Medicine
ER -