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Hyperparathyroidism: a prerequisite for Zollinger-Ellison syndrome in multiple endocrine adenomatosis Type 1--report of a further family and a review of th literature.
Q J Med. 1980 Winter; 49(193):69-76.QJ

Abstract

A family with Multiple Endocrine Adenomatosis Type 1 (MEA 1) is described. Of the 59 members, 15 were affected. Zollinger-Ellison syndrome was present in six individuals of whom the five available for study had hyperparathyroidism. The youngest of these patients with Zollinger-Ellison Syndrome was 25 years old. Hyperparathyroidism alone was present in nine individuals of whom the eldest was 30 years old. Three other members had raised serum gastrin levels but lacked symptoms suggestive of Zollinger-Ellison syndrome and in these individuals, the serum calcium levels were normal. A review of the literature confirms the finding that, in MEA 1, Zollinger-Ellison syndrome has not been shown to occur in the absence of hypercalcaemia. Screening of affected members of such families can therefore be restricted to the measurements of serum calcium levels.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6107954

Citation

Betts, J B., et al. "Hyperparathyroidism: a Prerequisite for Zollinger-Ellison Syndrome in Multiple Endocrine Adenomatosis Type 1--report of a Further Family and a Review of Th Literature." The Quarterly Journal of Medicine, vol. 49, no. 193, 1980, pp. 69-76.
Betts JB, O'Malley BP, Rosenthal FD. Hyperparathyroidism: a prerequisite for Zollinger-Ellison syndrome in multiple endocrine adenomatosis Type 1--report of a further family and a review of th literature. Q J Med. 1980;49(193):69-76.
Betts, J. B., O'Malley, B. P., & Rosenthal, F. D. (1980). Hyperparathyroidism: a prerequisite for Zollinger-Ellison syndrome in multiple endocrine adenomatosis Type 1--report of a further family and a review of th literature. The Quarterly Journal of Medicine, 49(193), 69-76.
Betts JB, O'Malley BP, Rosenthal FD. Hyperparathyroidism: a Prerequisite for Zollinger-Ellison Syndrome in Multiple Endocrine Adenomatosis Type 1--report of a Further Family and a Review of Th Literature. Q J Med. 1980;49(193):69-76. PubMed PMID: 6107954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperparathyroidism: a prerequisite for Zollinger-Ellison syndrome in multiple endocrine adenomatosis Type 1--report of a further family and a review of th literature. AU - Betts,J B, AU - O'Malley,B P, AU - Rosenthal,F D, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 69 EP - 76 JF - The Quarterly journal of medicine JO - Q J Med VL - 49 IS - 193 N2 - A family with Multiple Endocrine Adenomatosis Type 1 (MEA 1) is described. Of the 59 members, 15 were affected. Zollinger-Ellison syndrome was present in six individuals of whom the five available for study had hyperparathyroidism. The youngest of these patients with Zollinger-Ellison Syndrome was 25 years old. Hyperparathyroidism alone was present in nine individuals of whom the eldest was 30 years old. Three other members had raised serum gastrin levels but lacked symptoms suggestive of Zollinger-Ellison syndrome and in these individuals, the serum calcium levels were normal. A review of the literature confirms the finding that, in MEA 1, Zollinger-Ellison syndrome has not been shown to occur in the absence of hypercalcaemia. Screening of affected members of such families can therefore be restricted to the measurements of serum calcium levels. SN - 0033-5622 UR - https://www.unboundmedicine.com/medline/citation/6107954/Hyperparathyroidism:_a_prerequisite_for_Zollinger_Ellison_syndrome_in_multiple_endocrine_adenomatosis_Type_1__report_of_a_further_family_and_a_review_of_th_literature_ L2 - http://www.diseaseinfosearch.org/result/7600 DB - PRIME DP - Unbound Medicine ER -