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The effect of cytosine arabinoside and bromodeoxyuridine on the appearance of tyrosine aminotransferase in cultured foetal hepatocytes of the rat.
Biochem J. 1980 Jun 15; 188(3):929-32.BJ

Abstract

1. The acquisition of dexamethasone-inducibility of tyrosine aminotransferase activity by hepatocytes cultured from 15-day-foetal rat liver is blocked in the presence of cytosine arabinoside. 2. Similar results are obtained in the presence of bormodeoxyuridine. 3. No effects on steroid-inducibility of tyrosine aminotransferase are obtained with either of the above compounds in hepatocytes cultured from 19-day-foetal liver. 4. the inhibitory effects of the agents are substantially reversed after their removal from the culture medium. 5. The effects of bromodeoxyuridine suggest that cell differentiation, with respect to tyrosine aminotransferase-inducibility, occurs in cultures of 15-day-doetal hepatocytes. 6. The effects of cytosine arabinoside suggest that such an event is dependent on mitosis.

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Authors

Yeoh GC
No affiliation info available
Oliver IT
No affiliation info available

MeSH

AnimalsBromodeoxyuridineCell DivisionCells, CulturedCytarabineDNALiverRatsTyrosine Transaminase

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6110421

Citation

Yeoh, G C., and I T. Oliver. "The Effect of Cytosine Arabinoside and Bromodeoxyuridine On the Appearance of Tyrosine Aminotransferase in Cultured Foetal Hepatocytes of the Rat." The Biochemical Journal, vol. 188, no. 3, 1980, pp. 929-32.
Yeoh GC, Oliver IT. The effect of cytosine arabinoside and bromodeoxyuridine on the appearance of tyrosine aminotransferase in cultured foetal hepatocytes of the rat. Biochem J. 1980;188(3):929-32.
Yeoh, G. C., & Oliver, I. T. (1980). The effect of cytosine arabinoside and bromodeoxyuridine on the appearance of tyrosine aminotransferase in cultured foetal hepatocytes of the rat. The Biochemical Journal, 188(3), 929-32.
Yeoh GC, Oliver IT. The Effect of Cytosine Arabinoside and Bromodeoxyuridine On the Appearance of Tyrosine Aminotransferase in Cultured Foetal Hepatocytes of the Rat. Biochem J. 1980 Jun 15;188(3):929-32. PubMed PMID: 6110421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of cytosine arabinoside and bromodeoxyuridine on the appearance of tyrosine aminotransferase in cultured foetal hepatocytes of the rat. AU - Yeoh,G C, AU - Oliver,I T, PY - 1980/6/15/pubmed PY - 1980/6/15/medline PY - 1980/6/15/entrez SP - 929 EP - 32 JF - The Biochemical journal JO - Biochem J VL - 188 IS - 3 N2 - 1. The acquisition of dexamethasone-inducibility of tyrosine aminotransferase activity by hepatocytes cultured from 15-day-foetal rat liver is blocked in the presence of cytosine arabinoside. 2. Similar results are obtained in the presence of bormodeoxyuridine. 3. No effects on steroid-inducibility of tyrosine aminotransferase are obtained with either of the above compounds in hepatocytes cultured from 19-day-foetal liver. 4. the inhibitory effects of the agents are substantially reversed after their removal from the culture medium. 5. The effects of bromodeoxyuridine suggest that cell differentiation, with respect to tyrosine aminotransferase-inducibility, occurs in cultures of 15-day-doetal hepatocytes. 6. The effects of cytosine arabinoside suggest that such an event is dependent on mitosis. SN - 0264-6021 UR - https://www.unboundmedicine.com/medline/citation/6110421/The_effect_of_cytosine_arabinoside_and_bromodeoxyuridine_on_the_appearance_of_tyrosine_aminotransferase_in_cultured_foetal_hepatocytes_of_the_rat_ L2 - https://portlandpress.com/biochemj/article-lookup/doi/10.1042/bj1880929 DB - PRIME DP - Unbound Medicine ER -