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Role of adrenaline and cyclic AMP in appearance of tyrosine aminotransferase in perinatal rat liver.
Biochem J. 1980 Sep 15; 190(3):685-90.BJ

Abstract

1. Adrenaline increased hepatic tyrosine aminotransferase activity when injected into foetal rats or 2-day-old rats. 2. The inhibition of the postnatal increase in tyrosine aminotransferase activity which occurred in adrenalectomized newborn rats rapidly overcome by injection of adrenaline or dibutyryl cyclic AMP. 3. The effects of adrenaline or dibutyryl cyclic AMP on the tyrosine aminotransferase activity in foetal, adrenalectomized newborn and 2-day-old rats could be partially or completely blocked by prior treatment with actinomycin D. 4. Dibutyryl cyclic AMP induced tyrosine aminotransferase activity in hepatocytes cultured from 15-day foetal rats in glucocorticoid-free medium. 5. Actinomycin D at 0.2 microgram/ml in the culture medium completely prevented the induction of tyrosine aminotransferase activity by dibutyryl cyclic AMP in cultured cells. 6. The results suggest that adrenaline and cyclic AMP stimulate a transcriptional event during induction of tyrosine aminotransferase in perinatal liver.

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Authors

Ghisalberti AV
No affiliation info available
Steele JG
No affiliation info available
Cake MH
No affiliation info available
McGrath MC
No affiliation info available
Oliver IT
No affiliation info available

MeSH

AdrenalectomyAnimalsBucladesineCells, CulturedCyclic AMPDactinomycinDexamethasoneEnzyme InductionEpinephrineLiverRatsTyrosine Transaminase

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6110423

Citation

Ghisalberti, A V., et al. "Role of Adrenaline and Cyclic AMP in Appearance of Tyrosine Aminotransferase in Perinatal Rat Liver." The Biochemical Journal, vol. 190, no. 3, 1980, pp. 685-90.
Ghisalberti AV, Steele JG, Cake MH, et al. Role of adrenaline and cyclic AMP in appearance of tyrosine aminotransferase in perinatal rat liver. Biochem J. 1980;190(3):685-90.
Ghisalberti, A. V., Steele, J. G., Cake, M. H., McGrath, M. C., & Oliver, I. T. (1980). Role of adrenaline and cyclic AMP in appearance of tyrosine aminotransferase in perinatal rat liver. The Biochemical Journal, 190(3), 685-90.
Ghisalberti AV, et al. Role of Adrenaline and Cyclic AMP in Appearance of Tyrosine Aminotransferase in Perinatal Rat Liver. Biochem J. 1980 Sep 15;190(3):685-90. PubMed PMID: 6110423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of adrenaline and cyclic AMP in appearance of tyrosine aminotransferase in perinatal rat liver. AU - Ghisalberti,A V, AU - Steele,J G, AU - Cake,M H, AU - McGrath,M C, AU - Oliver,I T, PY - 1980/9/15/pubmed PY - 1980/9/15/medline PY - 1980/9/15/entrez SP - 685 EP - 90 JF - The Biochemical journal JO - Biochem J VL - 190 IS - 3 N2 - 1. Adrenaline increased hepatic tyrosine aminotransferase activity when injected into foetal rats or 2-day-old rats. 2. The inhibition of the postnatal increase in tyrosine aminotransferase activity which occurred in adrenalectomized newborn rats rapidly overcome by injection of adrenaline or dibutyryl cyclic AMP. 3. The effects of adrenaline or dibutyryl cyclic AMP on the tyrosine aminotransferase activity in foetal, adrenalectomized newborn and 2-day-old rats could be partially or completely blocked by prior treatment with actinomycin D. 4. Dibutyryl cyclic AMP induced tyrosine aminotransferase activity in hepatocytes cultured from 15-day foetal rats in glucocorticoid-free medium. 5. Actinomycin D at 0.2 microgram/ml in the culture medium completely prevented the induction of tyrosine aminotransferase activity by dibutyryl cyclic AMP in cultured cells. 6. The results suggest that adrenaline and cyclic AMP stimulate a transcriptional event during induction of tyrosine aminotransferase in perinatal liver. SN - 0264-6021 UR - https://www.unboundmedicine.com/medline/citation/6110423/Role_of_adrenaline_and_cyclic_AMP_in_appearance_of_tyrosine_aminotransferase_in_perinatal_rat_liver_ L2 - https://portlandpress.com/biochemj/article-lookup/doi/10.1042/bj1900685 DB - PRIME DP - Unbound Medicine ER -