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Somatostatin and diabetes.
Am J Med. 1981 Mar; 70(3):619-26.AJ

Abstract

Somatostatin, a tetradecapeptide originally isolated from the hypothalamus on the basis of its ability to inhibit the secretion of growth hormone, is now known to be widely distributed in various endocrine and gastrointestinal tissues and to have diverse actions, including inhibition of insulin and glucagon secretion. The location of somatostatin in pancreatic islet D cells suggests that it may act as a local regulator of insulin and glucagon secretion. Changes in islet D-cell function in experimentally-induced and spontaneous diabetes in animals suggest that the peptide may be involved in the pathogenesis of diabetes. Clinical studies with the peptide have provided insight into the physiologic roles of glucagon and growth hormone, and have indicated a potential therapeutic use for somatostatin in diabetes in man.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

6111219

Citation

Gerich, J E.. "Somatostatin and Diabetes." The American Journal of Medicine, vol. 70, no. 3, 1981, pp. 619-26.
Gerich JE. Somatostatin and diabetes. Am J Med. 1981;70(3):619-26.
Gerich, J. E. (1981). Somatostatin and diabetes. The American Journal of Medicine, 70(3), 619-26.
Gerich JE. Somatostatin and Diabetes. Am J Med. 1981;70(3):619-26. PubMed PMID: 6111219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Somatostatin and diabetes. A1 - Gerich,J E, PY - 1981/3/1/pubmed PY - 1981/3/1/medline PY - 1981/3/1/entrez SP - 619 EP - 26 JF - The American journal of medicine JO - Am J Med VL - 70 IS - 3 N2 - Somatostatin, a tetradecapeptide originally isolated from the hypothalamus on the basis of its ability to inhibit the secretion of growth hormone, is now known to be widely distributed in various endocrine and gastrointestinal tissues and to have diverse actions, including inhibition of insulin and glucagon secretion. The location of somatostatin in pancreatic islet D cells suggests that it may act as a local regulator of insulin and glucagon secretion. Changes in islet D-cell function in experimentally-induced and spontaneous diabetes in animals suggest that the peptide may be involved in the pathogenesis of diabetes. Clinical studies with the peptide have provided insight into the physiologic roles of glucagon and growth hormone, and have indicated a potential therapeutic use for somatostatin in diabetes in man. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/6111219/Somatostatin_and_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9343(81)90584-2 DB - PRIME DP - Unbound Medicine ER -