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Effects of antisomatostatin and antiglucagon sera on insulin release from isolated Langerhans' islets of rats.
Horm Metab Res. 1981 Feb; 13(2):78-80.HM

Abstract

Effects of antisomatostatin and antiglucagon sera on insulin secretion were studied in isolated pancreatic islets of rats. Addition of antisomatostatin or antiglucagon serum to the incubation medium containing 5.5 mM glucose significantly increased insulin secretion from the islets. In contrast, these effect were not apparent when the glucose concentration was elevated to 20 mM. In the presence of antiglucagon serum the free glucagon concentration in the medium was decreased, while the total glucagon was markedly increased, suggesting that the antiglucagon serum caused an increase in glucagon secretion. These results suggest that A- and D-cells may play an important role in regulating insulin release at physiologic glucose concentration.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6112197

Citation

Tanigawa, K, et al. "Effects of Antisomatostatin and Antiglucagon Sera On Insulin Release From Isolated Langerhans' Islets of Rats." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 13, no. 2, 1981, pp. 78-80.
Tanigawa K, Kuzuya H, Sakurai H, et al. Effects of antisomatostatin and antiglucagon sera on insulin release from isolated Langerhans' islets of rats. Horm Metab Res. 1981;13(2):78-80.
Tanigawa, K., Kuzuya, H., Sakurai, H., Seino, Y., Seino, S., Tsuda, K., & Imura, H. (1981). Effects of antisomatostatin and antiglucagon sera on insulin release from isolated Langerhans' islets of rats. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 13(2), 78-80.
Tanigawa K, et al. Effects of Antisomatostatin and Antiglucagon Sera On Insulin Release From Isolated Langerhans' Islets of Rats. Horm Metab Res. 1981;13(2):78-80. PubMed PMID: 6112197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of antisomatostatin and antiglucagon sera on insulin release from isolated Langerhans' islets of rats. AU - Tanigawa,K, AU - Kuzuya,H, AU - Sakurai,H, AU - Seino,Y, AU - Seino,S, AU - Tsuda,K, AU - Imura,H, PY - 1981/2/1/pubmed PY - 1981/2/1/medline PY - 1981/2/1/entrez SP - 78 EP - 80 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 13 IS - 2 N2 - Effects of antisomatostatin and antiglucagon sera on insulin secretion were studied in isolated pancreatic islets of rats. Addition of antisomatostatin or antiglucagon serum to the incubation medium containing 5.5 mM glucose significantly increased insulin secretion from the islets. In contrast, these effect were not apparent when the glucose concentration was elevated to 20 mM. In the presence of antiglucagon serum the free glucagon concentration in the medium was decreased, while the total glucagon was markedly increased, suggesting that the antiglucagon serum caused an increase in glucagon secretion. These results suggest that A- and D-cells may play an important role in regulating insulin release at physiologic glucose concentration. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/6112197/Effects_of_antisomatostatin_and_antiglucagon_sera_on_insulin_release_from_isolated_Langerhans'_islets_of_rats_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1019178 DB - PRIME DP - Unbound Medicine ER -