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[Misinterpretation of thyroid function caused by alteration in thyroxine binding globulin concentration (author's transl)].
Monatsschr Kinderheilkd. 1981 Jun; 129(6):367-9.MK

Abstract

Two children with undiagnosed TBG alteration were incorrectly treated for hyperthyroidism and hypothroidism, respectively. The first child exhibited hyperthyroxinemia and hypertriiodothyroninemia caused by an increase of TBG. The unoccupied binding sites of serum for thyroid hormones measured by T3-uptake were elevated as usually seen in hypothyroidism. In contrast thyroxine and triiodothyronine were extremely low in the serum of the second patient due to inherited TBG deficiency. T3-uptake was decreased to a value normally found in hyperthyroidism. The paradoxical results of T3-uptake and thyroxine levels indicated changes of concentrations of thyronine binding proteins. The quantitative determination of TBG established the correct diagnosis of TBG elevation and TBG deficiency, respectively.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

6114420

Citation

Heidemann, P, and P Stubbe. "[Misinterpretation of Thyroid Function Caused By Alteration in Thyroxine Binding Globulin Concentration (author's Transl)]." Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde, vol. 129, no. 6, 1981, pp. 367-9.
Heidemann P, Stubbe P. [Misinterpretation of thyroid function caused by alteration in thyroxine binding globulin concentration (author's transl)]. Monatsschr Kinderheilkd. 1981;129(6):367-9.
Heidemann, P., & Stubbe, P. (1981). [Misinterpretation of thyroid function caused by alteration in thyroxine binding globulin concentration (author's transl)]. Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde, 129(6), 367-9.
Heidemann P, Stubbe P. [Misinterpretation of Thyroid Function Caused By Alteration in Thyroxine Binding Globulin Concentration (author's Transl)]. Monatsschr Kinderheilkd. 1981;129(6):367-9. PubMed PMID: 6114420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Misinterpretation of thyroid function caused by alteration in thyroxine binding globulin concentration (author's transl)]. AU - Heidemann,P, AU - Stubbe,P, PY - 1981/6/1/pubmed PY - 1981/6/1/medline PY - 1981/6/1/entrez SP - 367 EP - 9 JF - Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde JO - Monatsschr Kinderheilkd VL - 129 IS - 6 N2 - Two children with undiagnosed TBG alteration were incorrectly treated for hyperthyroidism and hypothroidism, respectively. The first child exhibited hyperthyroxinemia and hypertriiodothyroninemia caused by an increase of TBG. The unoccupied binding sites of serum for thyroid hormones measured by T3-uptake were elevated as usually seen in hypothyroidism. In contrast thyroxine and triiodothyronine were extremely low in the serum of the second patient due to inherited TBG deficiency. T3-uptake was decreased to a value normally found in hyperthyroidism. The paradoxical results of T3-uptake and thyroxine levels indicated changes of concentrations of thyronine binding proteins. The quantitative determination of TBG established the correct diagnosis of TBG elevation and TBG deficiency, respectively. SN - 0026-9298 UR - https://www.unboundmedicine.com/medline/citation/6114420/[Misinterpretation_of_thyroid_function_caused_by_alteration_in_thyroxine_binding_globulin_concentration__author's_transl_]_ L2 - https://medlineplus.gov/hyperthyroidism.html DB - PRIME DP - Unbound Medicine ER -